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PF-CBP1 [ISOX INACT],≥98% (HPLC)

别名:4-(2-(5-(3,5-Dimethylisoxazol-4-yl)-2-(4-propoxyphenethyl)-1H-benzo[d]imidazol-1-yl)ethyl)morpholine, PF-06670910, PF CBP1, 5-(Dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-2-[2-(4-propoxyphenyl)ethyl]-1H-1,3-benzodiazole

Empirical Formula (Hill Notation): C29H36N4O3 分子量: 488.62 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0325
CAS号: 1962928-21-7
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$354.21

说明

一般描述

The gene CBP (CREB binding protein) is mapped to human chromosome 16p13.
基因 CBP(CREB 结合蛋白)定位于人类染色体 16p13。
 

包装

5, 25 mg in glass bottle
 

生化/生理作用

CBP is a transcriptional coactivator. The protein is a link between the DNA-associated transcription factors and the RNA polymerase 2 complex. It also exhibits histone acetyltransferase activity.
PF-CBP1 is potent and highly-selective inhibitor of the bromodomain of CREB binding protein (CBP BRD) that down regulates targets of CBP in macrophages primary neurons. Also, PF-CBP1 significantly reduces levels of RGS4 mRNA levels in neurons.
 
CBP 是一种转录共激活因子。 该蛋白质是 DNA 相关转录因子和 RNA 聚合酶 2 复合物之间的纽带。 它还表现出组蛋白乙酰转移酶活性。
PF-CBP1 是 CREB 结合蛋白 (CBP BRD) 溴结构域的强效和高选择性抑制剂,可下调巨噬细胞原代神经元中的 CBP 靶标。 此外,PF-CBP1 显着降低神经元中 RGS4 mRNA 的水平。
 

其他说明

This compound was developed by Pfizer for Gene Regulation research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

创始人

Pfizer

储存温度

room temp

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16