sevenspikes.themes.common.filters
sevenspikes.themes.common.closemenu

PF-5006739,≥98% (HPLC)

别名:PF5006739;4-{4-(4-Fluorophenyl)-1-1-(1,2-oxazol-3-ylmethyl)piperidin-4-yl-1H-imidazol-5-yl}pyrimidin-2-amine, 4-4-(4-Fluorophenyl)-1-1-(3-isoxazolylmethyl)-4-piperidinyl-1H-imidazol-5-yl-2-Pyrimidinamine

Empirical Formula (Hill Notation): C22H22FN7O CAS号: 1293395-67-1 分子量: 419.45 MDL编号: MFCD28386023 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0246
CAS号: 1293395-67-1
MDL号: MFCD28386023
增值税发票 √ 免费送货 √ 订货电话:010-68689484
$354.21

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

PF-5006739 is a potent inhibitor of casein kinases 1 delta (CK1δ) and 1 epsilon (CK1ε), key regulators of the suprachiasmatic nucleus (SCN) central clock and also linked to the development of drug addiction through PERIOD proteins (PER1–3) and dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) modulation. PF-5006739 has low nM in vitro potency for CK1δ/ε (IC50 values of 3.9 nM for CK1δ and 17.0 nM for CK1ε) and high kinome selectivity. PF-5006739 induced profound phase delays in circadian periodicity in both nocturnal and diurnal animal models and attenuated opioid drug-seeking behavior in a rodent operant reinstatement model.
 
PF-5006739 是酪蛋白激酶 1 delta (CK1δ) 和 1 epsilon (CK1ε) 的强效抑制剂,它们是视交叉上核 (SCN) 中央时钟的关键调节因子,并且还通过 PERIOD 蛋白 (PER1-3) 与药物成瘾的发展有关 和多巴胺和 cAMP 调节的神经元磷蛋白 (DARPP-32) 调节。 PF-5006739 对 CK1δ/ε 具有低 nM 体外效力(CK1δ 的 IC50 值为 3.9 nM,CK1ε 的 IC50 值为 17.0 nM)和高激酶组选择性。 PF-5006739 在夜间和昼夜动物模型中引起昼夜节律周期的显着相位延迟,并在啮齿动物操作性恢复模型中减弱阿片类药物寻求行为。
 

其他说明

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

DMSO: 10 mg/mL, clear

创始人

Pfizer

储存温度

room temp

SMILES string

FC(C=C1)=CC=C1C2=C(C3=CC=NC(N)=N3)N(C4CCN(CC5=NOC=C5)CC4)C=N2

 

安全信息

象形图

Skull and crossbones

警示用语:

Danger

危险声明

预防措施声明

RIDADR

UN 2811 6.1 / PGIII

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16