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PF-3644022 hydrate,≥98% (HPLC)

别名:(10R)-9,10,11,12-tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-1,4diazepino5′,6′:4,5thieno3,2-fquinolin-8-one hydrate

Empirical Formula (Hill Notation): C21H18N4OS · xH2O 分子量: 374.46 (anhydrous basis) MDL编号: MFCD21363374 PubChem化学物质编号: 329823762 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0188
CAS号: 1276121-88-0
MDL号: MFCD21363374
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$384.00

说明

PF-3644022 水合物已用于抑制人骨肉瘤细胞 (U2OS) 和结肠直肠癌细胞 (CT26) 中的丝裂原活化蛋白激酶 2 (MK2)。 PF-3644022 是丝裂原活化蛋白激酶活化蛋白激酶 2 (MK2; Ki = 3 nM) 的有效抑制剂。 PF-3644022 抑制 LPS 刺激的人全血中 TNFa 和 IL-6 的产生(IC50 分别为 1.6 和 10.3 μM),并阻止链球菌细胞壁诱导的大鼠关节炎中的 TNFa 产生和爪肿胀。

应用

PF-3644022 hydrate has been used for the inhibition of mitogen-activated protein kinase 2 (MK2) in human osteosarcoma cells (U2OS) and in colorectal carcinoma cells (CT26).
 

包装

5, 25 mg in glass bottle
 

生化/生理作用

PF-3644022 is a potent inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MK2; Ki = 3 nM). PF-3644022 inhibits TNFa and IL-6 production in LPS-stimulated human whole blood (IC50 = 1.6 and 10.3 μM, respectively) and blocks TNFα production and paw swelling in a streptococcal cell wall-induced arthritis in rats.
 

特点和优势

This compound is featured on the MAPKAPs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
 

其他说明

PF3644022 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the PF3644022 probe summary on the Chemical Probes Portal website.
This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Pfizer is a registered trademark of Pfizer, Inc.
 

属性

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

yellow to orange

溶解性

DMSO: ≥15 mg/mL

创始人

Pfizer

储存温度

2-8°C

SMILES string

O.CC@@H1CNc2c(sc3ccc4nc(ccc4c23)-c5ccc(C)nc5)C(=O)N1

InChI

1S/C21H18N4OS.H2O/c1-11-3-4-13(10-22-11)15-6-5-14-16(25-15)7-8-17-18(14)19-20(27-17)21(26)24-12(2)9-23-19;/h3-8,10,12,23H,9H2,1-2H3,(H,24,26);1H2/t12-;/m1./s1

InChI key

WHVUIWUUCVXAGR-UTONKHPSSA-N

 

安全信息

象形图

Exclamation mark

警示用语:

Warning

危险声明

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16