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PF-2545920 hydrochloride,≥97% (HPLC)

别名:2-4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl-quinoline hydrochloride, PF-920 hydrochloride, MP-10 hydrochloride, PF-02545920 hydrochloride

Empirical Formula (Hill Notation): C25H20N4O · HCl CAS号: 898562-94-2 (free base) 分子量: 428.91 MDL编号: MFCD30489759 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0351
CAS号: 898562-94-2
MDL号: MFCD30489759
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$354.21

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

PF-2545920 hydrochloride (MP-10) is a potent and selective cyclic nucleotide phosphodiesterase (PDE) 10A competitive inhibitor with a reported IC50 value of 1.26 nM. PDE10A hydrolyzes both cAMP and cGMP, and is highly expressed in medium spiny neurons of the mammalian striatum and in basal ganglia areas where D1 and D2 dopamine receptors are expressed. PF-2545920 has been studied for treatment of schizophrenia and Huntington′s disease.
PF-2545920 盐酸盐 (MP-10) 是一种有效的选择性环核苷酸磷酸二酯酶 (PDE) 10A 竞争性抑制剂,据报道 IC50 值为 1.26 nM。 PDE10A 水解 cAMP 和 cGMP,并且在哺乳动物纹状体的中等多刺神经元和表达 D1 和 D2 多巴胺受体的基底神经节区域中高度表达。 PF-2545920 已被研究用于治疗精神分裂症和亨廷顿病。
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥97% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to brown

溶解性

DMSO: 20 mg/mL, clear

创始人

Pfizer

储存温度

room temp

SMILES string

CN1C=C(C2=CC=NC=C2)C(C(C=C3)=CC=C3OCC4=NC5=CC=CC=C5C=C4)=N1.HCl

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16