PF-2545920 hydrochloride，≥97% (HPLC)

图片 PF-2545920 hydrochloride，≥97% (HPLC)
别名：2-4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl-quinoline hydrochloride, PF-920 hydrochloride, MP-10 hydrochloride, PF-02545920 hydrochloride

Empirical Formula (Hill Notation): C25H20N4O · HCl CAS号: 898562-94-2 (free base) 分子量: 428.91 MDL编号: MFCD30489759 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: PZ0351
CAS号: 898562-94-2
MDL号: MFCD30489759
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说明

生化/生理作用

PF-2545920 hydrochloride (MP-10) is a potent and selective cyclic nucleotide phosphodiesterase (PDE) 10A competitive inhibitor with a reported IC50 value of 1.26 nM. PDE10A hydrolyzes both cAMP and cGMP, and is highly expressed in medium spiny neurons of the mammalian striatum and in basal ganglia areas where D1 and D2 dopamine receptors are expressed. PF-2545920 has been studied for treatment of schizophrenia and Huntington′s disease.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 
 

属性

质量水平

100

检测方案

≥97% (HPLC)

形式

powder

manufacturer/tradename

Pfizer®

颜色

white to brown

溶解性

DMSO: 20 mg/mL, clear

创始人

Pfizer

储存温度

room temp

SMILES string

CN1C=C(C2=CC=NC=C2)C(C(C=C3)=CC=C3OCC4=NC5=CC=CC=C5C=C4)=N1.[H]Cl

InChI

1S/C25H20N4O/c1-29-16-23(18-12-14-26-15-13-18)25(28-29)20-7-10-22(11-8-20)30-17-21-9-6-19-4-2-3-5-24(19)27-21/h2-16H,17H2,1H3

InChI key

AZEXWHKOMMASPA-UHFFFAOYSA-N

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
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