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PF-06672131,≥95% (HPLC)

别名:PF-06672131;(2E)-N-4-(3-Chloro-4-fluorophenyl)amino-7-(2-propyn-1-yloxy)-6-quinazolinyl-4-(dimethylamino)-2-butenamide, (E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(prop-2-yn-1-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide, Probe 8

Empirical Formula (Hill Notation): C23H21ClFN5O2 CAS号: 1621002-27-4 分子量: 453.90 MDL编号: MFCD28386021 PubChem化学物质编号: 329823789
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0243
CAS号: 1621002-27-4
MDL号: MFCD28386021
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$354.21

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

PF-06672131 is a selective EGFR kinase inhibitor thought to covalently react with active-site cysteine residues in the ATP binding pocket. PF-06672131 has been used as a probe for proteomic analysis to identify off-target binding substrates. The dimethylaminomethyl (DMAM) group appears to increase compound stability in cancer cells with a resultant increase in protein reactivity from selective EGFR binding to widespread proteome-wide reactivity after treatment.
PF-06672131 是一种选择性 EGFR 激酶抑制剂,被认为与 ATP 结合口袋中的活性位点半胱氨酸残基发生共价反应。 PF-06672131 已被用作蛋白质组学分析的探针,以识别脱靶结合底物。 二甲氨基甲基 (DMAM) 基团似乎增加了癌细胞中的化合物稳定性,从而导致从选择性 EGFR 结合到治疗后广泛的蛋白质组范围反应性的蛋白质反应性增加。
 

其他说明

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥95% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

创始人

Pfizer

储存温度

room temp

SMILES string

FC(C=C1)=C(Cl)C=C1NC2=NC=NC3=CC(OCC#C)=C(NC(/C=C/CN(C)C)=O)C=C32

 

安全信息

象形图

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警示用语:

Warning

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16