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PF-06439015 methanesulfonate salt,≥98% (HPLC)

别名:PF06439015甲磺酸盐;PF-06439015 mesylate, 2R-(5-{6-Amino-5-[1R-(5-fluoro-2-[1,2,3]triazol-2-yl-phenyl)-ethoxy]-pyridin-3-yl}-4-methyl-thiazol-2-yl)-propane-1,2-diol methanesulfonate, PF-06439015 methanesulfonate

Empirical Formula (Hill Notation): C22H23FN6O3S · CH3SO3H 分子量: 566.63 MDL编号: MFCD27978372 PubChem化学物质编号: 329823778 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0221
MDL号: MFCD27978372
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€228.53

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

PF-06439015 is a potent and selective inihibitor that overcomes clinical ALK (receptor tyrosine kinase anaplastic lymphoma kinase) mutations resistant to Crizotinib. PF-06439015 is potent across a broad panel of ALK mutant cell lines with an IC50 of 6.6 nM for tumor growth inhibition in a crizotinib-resistant cell line (H3122-L1196M).
 
PF-06439015 是一种有效的选择性抑制剂,可克服对克唑替尼耐药的临床 ALK(受体酪氨酸激酶间变性淋巴瘤激酶)突变。 PF-06439015 在广泛的 ALK 突变细胞系中有效,在克唑替尼耐药细胞系 (H3122-L1196M) 中抑制肿瘤生长的 IC50 为 6.6 nM。
 

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
 

其他说明

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

H2O: 15 mg/mL, clear

创始人

Pfizer

储存温度

room temp

SMILES string

OC[C@](O)(C)C(S1)=NC(C)=C1C2=CN=C(N)C(O[C@H](C)C3=C(N4N=CC=N4)C=CC(F)=C3)=C2.CS(O)(=O)=O

InChI

1S/C22H23FN6O3S.CH4O3S/c1-12-19(33-21(28-12)22(3,31)11-30)14-8-18(20(24)25-10-14)32-13(2)16-9-15(23)4-5-17(16)29-26-6-7-27-29;1-5(2,3)4/h4-10,13,30-31H,11H2,1-3H3,(H2,24,25);1H3,(H,2,3,4)/t13-,22-;/m1./s1

InChI key

CVPQOLHPYNCJHK-RSUIGRPMSA-N

 

安全信息

象形图

Exclamation mark

警示用语:

Warning

危险声明

预防措施声明

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16