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PF-06297470,≥98% (HPLC)

别名:PF06297470;1-甲基-3-(4-甲基-3-吡啶基)-6-(2-吡啶基甲氧基)-1H-吡唑并[3,4-b]吡嗪;1-Methyl-3-(4-methyl-3-pyridinyl)-6-(2-pyridinylmethoxy)-1H-pyrazolo[3,4-b]pyrazine

Empirical Formula (Hill Notation): C18H16N6O CAS号: 1539296-45-1 分子量: 332.36 MDL编号: MFCD28100803 PubChem化学物质编号: 329823777
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0219
CAS号: 1539296-45-1
MDL号: MFCD28100803
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$354.21

说明

生化/生理作用

PF-06297470 is a potent negative allosteric modulator of the Metabotropic Glutamate Receptor 5 (mGluR5). PF-06297470 binds to mGluR5 with a Ki of 0.9 nM. The compound PF-06297470 displays slight antagonism of mGluR1 (IC50 = 30.5 mM), with no agonist or antagonist activities against any other mGlu receptor subtype at concentrations up to 50 mM. PF-06297470 reduces dyskinesia in a rodent (MPTP)-rendered Parkinsonian model of L-DOPA-induced dyskinesia (PD-LID).
 
PF-06297470 是一种有效的代谢型谷氨酸受体 5 (mGluR5) 的负变构调节剂。 PF-06297470 与 mGluR5 结合,Ki 为 0.9 nM。 化合物 PF-06297470 显示出对 mGluR1 的轻微拮抗作用 (IC50 = 30.5 mM),在高达 50 mM 的浓度下对任何其他 mGlu 受体亚型没有激动剂或拮抗剂活性。 PF-06297470 在啮齿动物 (MPTP) 呈现的 L-DOPA 诱发的运动障碍 (PD-LID) 帕金森模型中减少运动障碍。
 

特点和优势

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
 

其他说明

This compound was developed by Pfizer for Neuroscience research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

创始人

Pfizer

储存温度

2-8°C

SMILES string

CN(N=C1C2=C(C)C=CN=C2)C3=C1N=CC(OCC4=NC=CC=C4)=N3

InChI

1S/C18H16N6O/c1-12-6-8-19-9-14(12)16-17-18(24(2)23-16)22-15(10-21-17)25-11-13-5-3-4-7-20-13/h3-10H,11H2,1-2H3

InChI key

RDLSKDOSNKLEAQ-UHFFFAOYSA-N

 

安全信息

象形图

Exclamation mark

警示用语:

Warning

危险声明

RIDADR

NONH for all modes of transport

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16