sevenspikes.themes.common.filters
sevenspikes.themes.common.closemenu

PF-05105679,≥98% (HPLC)

别名:PF05105679, 3-(1R)-1-(4-Fluorophenyl)ethyl(3-quinolinylcarbonyl)aminomethyl-benzoic acid, (R)-3-(1-(4-fluorophenyl)ethyl)(quinolin-3-ylcarbonyl)aminomethylbenzoic acid

Empirical Formula (Hill Notation): C26H21FN2O3 CAS号: 1398583-31-7 分子量: 428.45 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0245
CAS号: 1398583-31-7
增值税发票 √ 免费送货 √ 订货电话:010-68689484
$354.21

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

PF-05105679 is an antagonist of the TRP (transient receptor potential) channel, also known as the cold and menthol receptor 1 (CMR1), with an IC50 value of 103 nM. PF-05105679 is in clinical trials for neuropathic pain. Participants taking PF-05105679 could hold their hands in a bucket of ice water for a long time before feeling pain, and pain-alleviating effects matched those of oxycodone for about one hour after administration.
Transient receptor potential cation channel subfamily M member 8 (TRPM8) antagonist, PF-05105679 (R)-3-(1-(4-fluorophenyl)ethyl)(quinolin-3-ylcarbonyl)aminomethylbenzoic acid acts as a clinical tool to assess the function of TRPM8 in modulating the body temperature. It also helps to determine its role in the treatment of pain in humans.
PF-05105679 is an antagonist of the TRP (transient receptor potential) channel, also known as the cold and menthol receptor 1 (CMR1), with an IC50 value of 103 nM. PF-05105679 is in clinical trials for neuropathic pain. Participants taking PF-05105679 could hold their hands in a bucket of ice water for a long time before feeling pain, and pain-alleviating effects matched those of oxycodone for about one hour after administration.
 
PF-05105679 是 TRP(瞬时受体电位)通道的拮抗剂,也称为冷和薄荷醇受体 1 (CMR1),IC50 值为 103 nM。 PF-05105679 正在进行神经病理性疼痛的临床试验。服用 PF-05105679 的参与者可以将手长时间放在一桶冰水中,然后才会感到疼痛,并且在服用后约 1 小时内,其镇痛效果与羟考酮相媲美。
瞬时受体电位阳离子通道亚家族 M 成员 8 (TRPM8) 拮抗剂 PF-05105679 (R)-3-(1-(4-fluorophenyl)ethyl)(quinolin-3-ylcarbonyl)aminomethylbenzoic acid 作为临床工具来评估TRPM8 调节体温的功能。它还有助于确定其在治疗人类疼痛中的作用。
PF-05105679 是 TRP(瞬时受体电位)通道的拮抗剂,也称为冷和薄荷醇受体 1 (CMR1),IC50 值为 103 nM。 PF-05105679 正在进行神经病理性疼痛的临床试验。服用 PF-05105679 的参与者可以将手长时间放在一桶冰水中,然后才会感到疼痛,并且在服用后约 1 小时内,其镇痛效果与羟考酮相媲美。
 

其他说明

This compound was developed by Pfizer for Neuroscience research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

DMSO: 10 mg/mL, clear

创始人

Pfizer

储存温度

room temp

 

安全信息

象形图

Exclamation mark

警示用语:

Warning

危险声明

RIDADR

NONH for all modes of transport

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16