sevenspikes.themes.common.filters
sevenspikes.themes.common.closemenu

PF-04802367,≥98% (HPLC)

别名:PF04802367;N-(3-(1H-1,2,4-Triazol-1-yl)propyl)-5-(3-chloro-4-methoxyphenyl)oxazole-4-carboxamide, PF-4802367, PF 04802367, PF-367

Empirical Formula (Hill Notation): C16H16ClN5O3 分子量: 361.78 PubChem化学物质编号: 329823833
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0313
CAS号: 1962178-27-3
增值税发票 √ 免费送货 √ 订货电话:010-68689484
$354.21

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

PF-04802367 is also known as N-(3-(1H-1,2,4-triazol-1-yl)propyl)-5-(3-chloro-4-methoxyphenyl)oxazole-4-carboxamide) or PF-367. It regulates tau phosphorylation in the brain.
PF-04802367 (PF-367) is a potent and specific ATP-competitive inhibitor of glycogen synthase kinase 3 (GSK-3α/β) with an IC50 value of 2.3 nM and >450-fold selectivity for GSK-3 in a panel of >400 neuroreceptors, enzymes and kinases. GSK-3 dysregulation has been implicated in the pathogenesis of neurological diseases including Alzheimer′s disease.
 
PF-04802367 也称为 N-(3-(1H-1,2,4-三唑-1-基)丙基)-5-(3-氯-4-甲氧基苯基)恶唑-4-甲酰胺)或PF- 367. 它调节大脑中的 tau 磷酸化。
PF-04802367 (PF-367) 是一种有效且特异性的 ATP 竞争性糖原合成酶激酶 3 (GSK-3α/β) 抑制剂,IC50 值为 2.3 nM,对 GSK-3 的选择性超过 450 倍。 > 400 种神经受体、酶和激酶。 GSK-3 失调与神经系统疾病(包括阿尔茨海默病)的发病机制有关。
 

其他说明

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

创始人

Pfizer

运输

wet ice

储存温度

−20°C

SMILES string

ClC1=CC(C2=C(C(NCCCN3N=CN=C3)=O)N=CO2)=CC=C1OC

InChI

1S/C16H16ClN5O3/c1-24-13-4-3-11(7-12(13)17)15-14(20-10-25-15)16(23)19-5-2-6-22-9-18-8-21-22/h3-4,7-10H,2,5-6H2,1H3,(H,19,23)

InChI key

RQFYFNAGNBUGFC-UHFFFAOYSA-N

 

安全信息

象形图

Exclamation mark

警示用语:

Warning

危险声明

预防措施声明

RIDADR

NONH for all modes of transport

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16