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PF-04457845,≥98% (HPLC)

别名:PF04457845;N-3-Pyridazinyl-4-3-5-(trifluoromethyl)-2-pyridinyloxyphenylmethylene-1-piperidinecarboxamide, PF-4457845, N-(3-pyridazinyl)-4-(3-5-trifluoromethyl-2-pyridinyloxybenzylidene)piperidine-1-carboxamide

Empirical Formula (Hill Notation): C23H20F3N5O2 CAS号: 1020315-31-4 分子量: 455.43 MDL编号: MFCD18782721 PubChem化学物质编号: 329823758 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0184
CAS号: 1020315-31-4
MDL号: MFCD18782721
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$233.74

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

PF-04457845 is a potent, orally active, irreversible inhibitor of fatty acid amide hydrolase (FAAH), the principle enzyme involved in the degradation of the endocannabinoid anandamide. PF-04457845 is a covalent inhibitor that carbamylates FAAH′s serine nucleophile. It was shown to be both potent and selective against other serine hydrolases. It has an IC50 value of 7.2 nM for human FAAH. The endocannabinoid system is a target for therapeutic pain relief. In a rat model of inflammatory pain, PF-04457845 produced significant reduction of inflammatory pain with efficacy comparable to that of naproxen at 10 mg/kg.
 

其他说明

This compound was developed by Pfizer for Neuroscience research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

DMSO: 20 mg/mL

创始人

Pfizer

储存温度

room temp

SMILES string

O=C(NC1=NN=CC=C1)N(CC2)CCC2=CC3=CC=CC(OC4=NC=C(C(F)(F)F)C=C4)=C3

InChI

1S/C23H20F3N5O2/c24-23(25,26)18-6-7-21(27-15-18)33-19-4-1-3-17(14-19)13-16-8-11-31(12-9-16)22(32)29-20-5-2-10-28-30-20/h1-7,10,13-15H,8-9,11-12H2,(H,29,30,32)

InChI key

BATCTBJIJJEPHM-UHFFFAOYSA-N

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16