PF04449913马来酸盐，PF-04449913 maleate salt；≥98% (HPLC)

别名：1-((2R,4R)-2-(1H-苯并[d]咪唑-2-基)-1-甲基哌啶-4-基)-3-(4-氰基苯基)脲；1-((2R,4R)-2-(1H-benzodimidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate salt, Glasdegib maleate salt

Empirical Formula (Hill Notation): C21H22N6O · C4H4O4 CAS号: 1095173-27-5 (free base) 分子量: 490.51 MDL编号: MFCD29037212 PubChem化学物质编号: 329823825 NACRES: NA.77

制造商品牌: 西格玛 Sigma-Aldrich

货号（SKU）: PZ0303

CAS号: 1095173-27-5

MDL号: MFCD29037212

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目录规格.SKU-Variant

5mg
25mg
100mg

说明

生化/生理作用

PF-04449913 (Glasdegib) is an orally bioavailable Hedgehog pathway inhibitor. PF-04449913 acts by binidng Smoothened (Smo) and blocking signal transduction. PF-04449913 has an IC₅₀ of 5 nM in the Gli-Luciferase assay. In a Phase I clinical trial in patients with advanced solid tumors, PF-04449913 caused disease stabilization in 34% of patients.

PF-04449913 maleate salt is also known as 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea. [1] It increases the differentiation of blood cells from hematopoietic precursors of the lymph gland medullary zone. This human Smo inhibitor protein is now under clinical trials to treat myeloid malignancies.[1]

其他说明

This compound was developed by Pfizer for Cytokines & Growth Factors research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法律信息

Sold for research purposes under agreement from Pfizer Inc.

Pfizer is a registered trademark of Pfizer, Inc.

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer^®

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

创始人

Pfizer

储存温度

room temp

SMILES string

OC(/C=C\C(O)=O)=O.CN1CCC@@H(NC(NC2=CC=C(C#N)C=C2)=O)CC@@H1C3=NC4=CC=CC=C4N3

InChI

1S/C21H22N6O.C4H4O4/c1-27-11-10-16(24-21(28)23-15-8-6-14(13-22)7-9-15)12-19(27)20-25-17-4-2-3-5-18(17)26-20;5-3(6)1-2-4(7)8/h2-9,16,19H,10-12H2,1H3,(H,25,26)(H2,23,24,28);1-2H,(H,5,6)(H,7,8)/b;2-1-/t16-,19-;/m1./s1

InChI key

VJCVKWFBWAVYOC-UIXXXISESA-N

Gene Information

human ... SMO(6608)

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

商品规格

属性名称	属性值
储存温度 Storage temp.	常温阴凉避光
全球实时库存 Availability √	美国St. Louis ≥ 20 \| 欧洲Eur. ≥ 16 \| 東京Tokyo ≥ 5 \| 香港与北京 ≥ 20

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