sevenspikes.themes.common.filters
sevenspikes.themes.common.closemenu

PF-04447943,≥98% (HPLC)

别名:1,5-Dihydro-6-(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl-1-(tetrahydro-2H-pyran-4-yl)-4H-pyrazolo3,4-dpyrimidin-4-one, PF 4447943, 6-(3S,4S)-4-Methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo3,4-dpyrimidin-4-one

Empirical Formula (Hill Notation): C20H25N7O2 CAS号: 1082744-20-4 分子量: 395.46 MDL编号: MFCD22665724 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0380
CAS号: 1082744-20-4
MDL号: MFCD22665724
增值税发票 √ 免费送货 √ 订货电话:010-68689484
$340.16

说明

生化/生理作用

PF-04447943 is a potent selective brain penetrant phosphodiesterase PDE9A inhibitor both potency (8 nM) and selectivity (>10 μM versus all the PDEs except PDE1C at >1 μM). It has been investigated for the treatment of cognitive disorders including Alzheimer′s Disease. PF-04447943 increased neurite outgrowth and synapse formation in hippocampal neurons in culture, exhibited synaptic stabilization in an amyloid precursor protein (APP) transgenic mouse model, and improved memory and enhanced attention in several animal models.
 
PF-04447943 是一种有效的选择性脑渗透性磷酸二酯酶 PDE9A 抑制剂,具有效力 (8 nM) 和选择性(>10 μM 与除 PDE1C 外的所有 PDE 相比 >1 μM)。 它已被研究用于治疗认知障碍,包括阿尔茨海默病。 PF-04447943 在培养的海马神经元中增加轴突生长和突触形成,在淀粉样前体蛋白 (APP) 转基因小鼠模型中表现出突触稳定性,并在几种动物模型中改善记忆和增强注意力。
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

创始人

Pfizer

储存温度

room temp

SMILES string

O=C1C2=C(N(C3CCOCC3)N=C2)N=C(C@H4C@H(C)CN(CC5=NC=CC=N5)C4)N1

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16