PF-04447943，≥98% (HPLC)

图片 PF-04447943，≥98% (HPLC)
别名：1,5-Dihydro-6-(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl-1-(tetrahydro-2H-pyran-4-yl)-4H-pyrazolo3,4-dpyrimidin-4-one, PF 4447943, 6-(3S,4S)-4-Methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo3,4-dpyrimidin-4-one

Empirical Formula (Hill Notation): C20H25N7O2 CAS号: 1082744-20-4 分子量: 395.46 MDL编号: MFCD22665724 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: PZ0380
CAS号: 1082744-20-4
MDL号: MFCD22665724
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说明

生化/生理作用

PF-04447943 is a potent selective brain penetrant phosphodiesterase PDE9A inhibitor both potency (8 nM) and selectivity (>10 μM versus all the PDEs except PDE1C at >1 μM). It has been investigated for the treatment of cognitive disorders including Alzheimer′s Disease. PF-04447943 increased neurite outgrowth and synapse formation in hippocampal neurons in culture, exhibited synaptic stabilization in an amyloid precursor protein (APP) transgenic mouse model, and improved memory and enhanced attention in several animal models.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 
 

属性

检测方案

≥98% (HPLC)

形式

powder

manufacturer/tradename

Pfizer®

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

创始人

Pfizer

储存温度

room temp

SMILES string

O=C1C2=C(N(C3CCOCC3)N=C2)N=C([C@H]4[C@H](C)CN(CC5=NC=CC=N5)C4)N1

InChI

1S/C20H25N7O2/c1-13-10-26(12-17-21-5-2-6-22-17)11-16(13)18-24-19-15(20(28)25-18)9-23-27(19)14-3-7-29-8-4-14/h2,5-6,9,13-14,16H,3-4,7-8,10-12H2,1H3,(H,24,25,28)/t13-,16-/m1/s1

InChI key

IWXUVYOOUMLUTQ-CZUORRHYSA-N

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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