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PF-04363467 hydrochloride,≥98% (HPLC)

别名:N-[4-[(2S)-4-Ethyl-2-morpholinyl]-2-methylphenyl]-4-(1-methylethyl)-benzenesulfonamide hydrochloride, (S)-N-[4-(4-Ethyl-2-morpholinyl)-2-methylphenyl]-4-(1-methylethyl)benzenesulfonamide hydrochloride, PF-4363467 hydrochloride

Empirical Formula (Hill Notation): C22H30N2O3S · HCl CAS号: 2040055-81-8 (free base) 分子量: 439.01 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0354
CAS号: 2040055-81-8
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$354.21

说明

包装

5, 25 mg in glass bottle

生化/生理作用

PF-4363467 hydrochloride is a Dopamine D3/D2 receptor antagonist. PF-4363467 has 100-fold selectivity for D3 with a Ki value of 3.1 nM for D3R compared to a Ki value of 692 nM for D2R and high selectivity for D3R compared to other biogenic amine receptors. PF-4363467 attenuated opioid drug-seeking behavior in a rat model of addiction without causing the extrapyramidal symptoms often associated with D2R antagonism.
 
PF-4363467 盐酸盐是一种多巴胺 D3/D2 受体拮抗剂。 PF-4363467 对 D3 具有 100 倍的选择性,对 D3R 的 Ki 值为 3.1 nM,而对 D2R 的 Ki 值为 692 nM,与其他生物胺受体相比,对 D3R 的选择性高。 PF-4363467 减弱了成瘾大鼠模型中的阿片类药物寻求行为,而不会引起通常与 D2R 拮抗作用相关的锥体外系症状。
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

H2O: 3 mg/mL, clear (warmed)

创始人

Pfizer

储存温度

room temp

SMILES string

[H]Cl.CC1=CC([C@H]2CN(CC)CCO2)=CC=C1NS(C3=CC=C(C(C)C)C=C3)(=O)=O

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16