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PD168393,≥98% (HPLC)

别名:PD-168393;4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline; N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-propenamide, PD 168393

Empirical Formula (Hill Notation): C17H13BrN4O CAS号: 194423-15-9 分子量: 369.22 MDL编号: MFCD02179207 PubChem化学物质编号: 329823812 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0285
CAS号: 194423-15-9
MDL号: MFCD02179207
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$231.74

说明

应用

PD168393 has been used in the acute inhibition of ErbB4.
PD168393 已用于 ErbB4 的急性抑制。
 

包装

5, 25 mg in glass bottle
 

生化/生理作用

PD168393 is a 6-acrylamido-4-anilinoquinazoline compound. It increases apoptosis in malignant peripheral nerve sheath tumor cells, stimulated by lysosomal dysfunction.
PD168393 is potent, cell-permeable, irreversible and selective inhibitor of EGF receptor (EGFR) tyrosine kinase and ErbB2. PD168393 has an IC50 value of 0.70 nM for EGFR, and is inactive against insulin, PDGFR, FGFR and PKC.
 
PD168393 是一种 6-丙烯酰胺基-4-苯胺基喹唑啉化合物。 它增加了由溶酶体功能障碍刺激的恶性外周神经鞘瘤细胞的凋亡。
PD168393 是 EGF 受体 (EGFR) 酪氨酸激酶和 ErbB2 的强效、细胞渗透性、不可逆和选择性抑制剂。 PD168393 对 EGFR 的 IC50 值为 0.70 nM,对胰岛素、PDGFR、FGFR 和 PKC 无活性。
 

其他说明

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

DMSO: 25 mg/mL, clear

创始人

Pfizer

储存温度

room temp

SMILES string

C=CC(NC1=CC2=C(NC3=CC=CC(Br)=C3)N=CN=C2C=C1)=O

InChI

1S/C17H13BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h2-10H,1H2,(H,21,23)(H,19,20,22)

InChI key

HTUBKQUPEREOGA-UHFFFAOYSA-N

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16