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PD166793 hydrate,≥98% (HPLC)

别名:(S)-2-(4′-Bromo-biphenyl-4-sulfonylamino)-3-methyl-butyric acid hydrate

Empirical Formula (Hill Notation): C17H18BrNO4S · xH2O 分子量: 412.30 (anhydrous basis) MDL编号: MFCD12912437 PubChem化学物质编号: 329819997 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): P0047
MDL号: MFCD12912437
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$396.73

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

PD166793 is a broad spectrum, but class-selective, MMP inhibitor (low nM at MMP-2 & 3 and low μM at MMP-1, 7 & 9). Adding PD166793 to the high-fat diet substantially reduced the rise in blood glucose. The improvement of glucose homeostasis in PD166793-treated ZDF rats was a result of the enhancement of β-cell function. It prevents β-cell dysfunction and diabetes in female ZDF rats on a high-fat diet. It has been shown to block left ventricular remodeling and dysfunction in a rat model of heart failure. Preservation of normoglycemia and normal glucose tolerance in compound PD166793-treated animals is accompanied by preservation of the high serum insulin levels that are a consequence of the insulin resistance present in these animals. It is not reversing insulin resistance these animals. The most striking effect of the compound is on pancreatic insulin content and β-cell volume.
 
PD166793 是一种广谱但具有类别选择性的 MMP 抑制剂(在 MMP-2 和 3 处为低 nM,在 MMP-1、7 和 9 处为低 μM)。 在高脂肪饮食中添加 PD166793 可显着降低血糖升高。 PD166793 治疗的 ZDF 大鼠葡萄糖稳态的改善是 β 细胞功能增强的结果。 它可以预防高脂肪饮食的雌性 ZDF 大鼠的 β 细胞功能障碍和糖尿病。 它已被证明可以阻止心力衰竭大鼠模型中的左心室重构和功能障碍。 在化合物 PD166793 治疗的动物中维持正常血糖和正常葡萄糖耐量伴随着维持高血清胰岛素水平,这是这些动物中存在的胰岛素抗性的结果。 它不会逆转这些动物的胰岛素抵抗。 该化合物最显着的作用是对胰腺胰岛素含量和 β 细胞体积。
 

特点和优势

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

solid

创始人

Pfizer

储存温度

2-8°C

SMILES string

O.CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c2ccc(Br)cc2)C(O)=O

InChI

1S/C17H18BrNO4S.H2O/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12;/h3-11,16,19H,1-2H3,(H,20,21);1H2/t16-;/m0./s1

InChI key

LUKRECOTGXWIDO-NTISSMGPSA-N

 

安全信息

个人防护装备

Eyeshields, Gloves, type N95 (US)

RIDADR

NONH for all modes of transport

WGK Germany

WGK 2

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16