NI-42 is a biased potent small molecule inhibitor of the bromodomain of the BRPF (bromodomain and PHD finger-containing) proteins, which are scaffolding proteins that assemble histone acetyltransferase (HAT) complexes of the MYST transcriptional coactivator family. NI-42 has an IC50 value of of 7.9 nM and is suitable for cellular and in vivo studies.
NI-42 是 BRPF（含溴结构域和 PHD 指）蛋白溴结构域的偏向有效小分子抑制剂，这些蛋白是组装 MYST 转录共激活因子家族的组蛋白乙酰转移酶 (HAT) 复合物的支架蛋白。 NI-42 的 IC50 值为 7.9 nM，适用于细胞和体内研究。
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