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Navitoclax [ABT263],≥99%, HPLC

别名:(R)-4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-morpholino-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide

MDL number MFCD12756219;Cas Number : 923564-51-6;分子式:C47H55ClF3N5O6S3;Molecular Weight : 974.63
制造商品牌: BSZH 科学公司
货号(SKU): N06053
CAS号: 923564-51-6
MDL号: MFCD12756219
增值税发票 √ 免费送货 √ 订货电话:010-68689484
HK$1,154.92

产品描述

包装

Navitoclax,ABT263是一种新的抗凋亡Bcl-2蛋白抑制剂,Ki<1nM,也是一种新的抗癌药物。可溶于DMSO (100mg/ml at 25°C)和DMF (~30mg/ml)

Biochem/physiol Actions

Navitoclax is an orally bioavailable, synthetic small-molecule antagonist of a subset of the B-cell leukemia 2 (Bcl-2) family of proteins with potential antineoplastic activity. ABT-263 selectively binds to apoptosis suppressor proteins Bcl-2, Bcl-XL, and Bcl-w and prevents their binding to the apoptotic effectors Bax and Bak proteins, which may trigger apoptosis in tumor cells overexpressing Bcl-2, Bcl-XL, and Bcl-w.

Navitoclax是B细胞白血病2(Bcl-2)家族蛋白的一个具有潜在抗肿瘤活性的口服生物合成小分子拮抗剂。 ABT-263选择性结合凋亡抑制蛋白Bcl-2,Bcl-XL和Bcl-w,并阻止它们与凋亡效应因子Bax和Bak蛋白结合,这可能会触发过表达Bcl-2,Bcl-XL, 和Bcl-w。

性质

Purity99.0%,HPLC
Storage temp.Keep in dark place,Sealed in dry,2-8 ℃
Physical Formsolid
mp114-116 ℃
Iupac NameN-[4-(4-{[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl}-1-piperazinyl)benzoyl]-4-({(1R)-3-(4-morpholinyl)-1-[(phenylsulfanyl)methyl]propyl}amino)-3-[(trifluoromethyl)sulfonyl]benzenesulfonamide
Inchi Code1S/C47H55ClF3N5O6S3/c1-46(2)20-18-42(34-8-12-37(48)13-9-34)36(31-46)32-55-22-24-56(25-23-55)39-14-10-35(11-15-39)45(57)53-65(60,61)41-16-17-43(44(30-41)64(58,59)47(49,50)51)52-38(19-21-54-26-28-62-29-27-54)33-63-40-6-4-3-5-7-40/h3-17,30,38,52H,18-29,31-33H2,1-2H3,(H,53,57)/t38-/m1/s1
Inchi KeyJLYAXFNOILIKPP-KXQOOQHDSA-N


安全信息

个人防护装备 EyeshieldsGlovestype N95 (US)
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 55 | 欧洲Eur. ≥ 128 | 東京Tokyo ≥ 44 | 香港与北京 ≥ 16