N-(4-溴苯基)-N-苯基丙烯酰胺；N-(4-Bromophenyl)-N-phenylacrylamide；≥95%

N-(4-Bromophenyl)-N-phenylacrylamide is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as ″undruggable,″ or difficult-to-target, proteins. This fragment electrophile, or ″scout″ fragment, can be used alone in fragment-based covalent ligand discovery or incorporated into bifunctional tools such as electrophilic PROTAC^® molecules for targeted protein degradation as demonstrated by the Cravatt Lab for E3 ligase discovery.

 

 

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license