N-叔丁氧羰基-四聚乙二醇-乙酸，BocNH-PEG4-acid；liquid

图片 N-叔丁氧羰基-四聚乙二醇-乙酸，BocNH-PEG4-acid；liquid
别名：2,2-二甲基-4-氧代-3,8,11,14,17-五氧杂-5-氮杂十九烷-19-酸；2,2-Dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azanonadecan-19-oic acid；Boc-NH-PEG4-CH2COOH

Empirical Formula (Hill Notation): C15H29NO8 CAS号: 876345-13-0 分子量: 351.39
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: 902551
CAS号: 876345-13-0
MDL号: MFCD30528568
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¥2,223.59

说明

应用

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. BocNH-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
 

其他说明

A Hexylchloride-Based Catch-and-Release System for Chemical Proteomic Applications
A Biocompatible Condensation Reaction for the Labeling of Terminal Cysteine Residues on Proteins
 

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
 
 

属性

形式

liquid

reaction suitability

reaction type: Pegylations
reagent type: cross-linking reagent

折射率

n/D 1.4641

密度

1.1395 g/mL

官能团

Boc
amine
carboxylic acid

储存温度

−20°C

SMILES string

OC(COCCOCCOCCOCCNC(OC(C)(C)C)=O)=O

 

安全信息

储存分类代码

10 - Combustible liquids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 10 | 欧洲Eur. ≥ 8 | 東京Tokyo ≥ 6 | 香港与北京 ≥ 60
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