N-叔丁基-α-苯基硝酮，N-tert-Butyl-α-phenylnitrone [PBN]；Most commonly-used free radical trap.,≥98% (GC)

Most commonly used free radical trap. An antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative diseases. Inhibits lipid peroxidation in rat liver microsomes. Also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.

Most commonly-used free radical trap. An antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. Inhibits lipid peroxidation in rat liver microsomes. Also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.

 

Cell permeable: no

Primary Target
Free radical trap

Product does not compete with ATP.

Reversible: no

 

Toxicity: Standard Handling (A)

 

Following reconstitution in DMSO aliquot and freeze (-20°C). Stock solutions in DMSO are stable for up to 2 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use.

 

Floyd, R.A. 1997. Adv. Pharmacol. 38, 361.
Miyajima, T., and Kotake, Y. 1995. Biochem. Biophys. Res. Commun. 215, 114.
Jazen, E.G., et al. 1994. in Frontiers of Reactive Oxygen Species in Biology and Medicine, (Asada, K., and Yoshikawa, T., eds.), pp. 431-434. Elsevier Science, Amsterdam.
Floyd, R.A. 1990. FASEB J. 4, 2587.

 

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