N-羟乙酰神经氨酸，N-Glycolylneuraminic acid [Neu5Glc, NeuNGl, Neu5Gc]；≥95% (HPLC), semisynthetic

N-Glycolylneuraminic acid (Neu5Gc) is a nonhuman sialic acid[1] molecule synthesized in pigs but not in humans, that has a role as a mammalian metabolite and an antigen. This hydroxylated form of sialic acid, specifically N-acetylneuraminic acid, features a glycolyl substituent on nitrogen and a beta-configuration at the anomeric center. The biosynthesis of N-glycolylneuraminic acid involves the enzymatic activity of cytidine monophosphate-N-acetylneuraminate (CMP-Neu5Ac) hydroxylase.
In humans, the absence of endogenous production results from a gene mutation affecting CMP-Neu5Ac hydroxylase, the enzyme responsible for converting N-acetylneuraminic acid into Neu5Gc. However, Neu5Gc can accumulate in human cells through external ingestion from dietary sources like red meat and dairy products. N-Glycolylneuraminic acid is a versatile compound that finds application in cell biology, metabolomics and biochemical research.

 

N-羟乙酰神经氨酸已被用于：

• 作为微量滴定生物膜（microtiter biofilm ）方法中的糖用于改善生物膜形成
• 作为标准品用于测定量蚕神经系统中的唾液酸，并用于发现不同发育阶段唾液酸的变化
• 作为高效液相色谱（HPLC）分析中的标准品用于以1,2-二氨基-4,5-亚甲基二氧苯（DMB）为荧光化合物检测唾液酸（Sia）分子

N-羟乙酰神经氨酸（Neu5Gc）是分析抗-Neu5Gc抗体和唾液酸结合蛋白的重要工具。

 

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