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N-(ε-马来酰亚胺基丙酸)酰肼三氟乙酸盐,N-(ε-maleimidocaproic acid) hydrazide, trifluoroacetic acid salt [EMCH];≥90%

别名:6-马来酰亚胺己酰肼三氟乙酸盐;6-Maleimidohexanehydrazide Trifluoroacetate;6-(2,5-二氧代-2,5-二氢-1H-吡咯-1-基)己烷肼2,2,2-三氟乙酸酯;6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate

Empirical Formula (Hill Notation): C10H15N3O3 · CF3CO2H 分子量: 339.27 PubChem化学物质编号: 329768826 NACRES: NA.22
制造商品牌: Sigma-Aldrich
货号(SKU): 803677
CAS号: 151038-94-7
MDL号: MFCD07357647
技术支持 √ 增值税发票 √ 免费送货 √ 质量保障 √
¥3,201.72

说明

一般描述

3,3′-N-[ε-Maleimidocaproic acid] hydrazide, trifluoroacetic acid salt (EMCH) is a water-soluble, heterobifunctional, membrane permeable crosslinker. It contains a sulfhydryl reactive maleimide group and carbonyl reactive hydrazide group at each end of a 6-carbon spacer arm. Maleimides react with sulfhydryls at pH 6.5-7.5 to form stable thiol ether bonds, along with release of the maleimide leaving group. Proteins with cysteine residues not involved in disulfide bond formation are targets for maleimide reactive groups. Carbonyl groups, whilst not found naturally on proteins can be formed by ring sugar reduction to form aldehydes which react with hydrazides at pH5.5-7.5.
 

特点和优势

  • Reactive groups: maleimide and hydrazide
  • Reactive towards: sulfhydryl groups and carbonyl (aldehyde) groups
  • Mid-length (11.8Å), sulfhydryl-to-aldehyde crosslinker with simple spacer arm (noncleavable)
  • Maleimide group reacts with sulfhydryl groups to form stable thioether linkages
  • Hydrazide group conjugates to oxidized sugars of glycoproteins and carbohydrates
  • Use sodium meta-periodate to oxidize glycosylation (e.g., sialic acid) to reactive aldehyde groups
  • Use with EDC to conjugate primary amine of hydrazide group to carboxyl groups

注意

This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.
 
 

属性

检测方案

≥90%

质量水平

形式

powder

分子量

339.27

reaction suitability

reagent type: cross-linking reagent

储存条件

desiccated

溶解性

water: soluble

官能团

hydrazide
maleimide

运输

ambient

储存温度

2-8°C

SMILES string

O=C(C=CC1=O)N1CCCCCC(N[NH3+])=O.[O-]C(C(F)(F)F)=O

InChI

1S/C10H15N3O3.C2HF3O2/c11-12-8(14)4-2-1-3-7-13-9(15)5-6-10(13)16;3-2(4,5)1(6)7/h5-6H,1-4,7,11H2,(H,12,14);(H,6,7)

InChI key

DRURMGRBAVYWCL-UHFFFAOYSA-N

 

安全信息

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32