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Madrasin,≥98% (HPLC)

别名:RNA剪接抑制剂;2-[((7-甲氧基-4-甲基-2-喹唑啉基)氨基] -5,6-二甲基-4(1H)-嘧啶酮(9CI);2-(7-甲氧基-4-甲基-喹唑啉-2-基氨基)-5,6-二甲基-3H-嘧啶-4-酮, 4(1H)-嘧啶酮,2-[((7-甲氧基-4-甲基-2-喹唑啉基)氨基] -5,6-二甲基-(9CI), 4(3H)-嘧啶酮,2-[((7-甲氧基-4-甲基-2-喹唑啉基)氨基] -5,6-二甲基-, DDD00107587;2-(7-Methoxy-4-methyl-quinazolin-2-ylamino)-5,6-dimethyl-3H-pyrimidin-4-one, 2-[(7-Methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-4(1H)-pyrimidinone (9CI), 4(1H)-Pyrimidinone, 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-(9CI), 4(3H)-Pyrimidinone, 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-, DDD00107587, RNAsplicing inhibitor

CAS号 374913-63-0 经验分子式(希尔表示法) C16H17N5O2 分子量 311.34 MDL number MFCD02233199 PubChem Substance ID 329825856
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML1409
CAS号: 374913-63-0
MDL号: MFCD02233199
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¥1,164.07

产品描述

Application

Madrasin has been used as a spliceosome inhibitor to inhibit pre-mRNA processing in 3T3-L1 cells.[2]

一种强力的细胞渗透拼接抑制剂,能够扰乱剪接体组装的前期过程。

包装

5, 25 mg in glass bottle

Biochem/physiol Actions

Madrasin is considered toxic to the cell at a higher concentration. At its minimal concentration, madrasin is known to induce subnuclear protein localization and cause cell cycle arrest.[1]

Madrasin 是一种高效的、细胞渗透性剪接抑制剂,可干扰剪接体组装的早期阶段。 Madrasin 使 A 复合体的剪接体装配停滞。

性质

Quality Level  100
assay  ≥98% (HPLC)
form  powder
color  white to dark brown
solubility  DMSO: 0.5 mg/mL, clear (warmed)
storage temp.  2-8°C
SMILES string  CC1=NC(NC(NC(C)=C2C)=NC2=O)=NC3=CC(OC)=CC=C31
InChI  1S/C16H17N5O2/c1-8-9(2)17-16(20-14(8)22)21-15-18-10(3)12-6-5-11(23-4)7-13(12)19-15/h5-7H,1-4H3,(H2,17,18,19,20,21,22)
InChI key  QQJIYKXTEMDJFM-UHFFFAOYSA-N


安全信息

符号 
GHS07  GHS07
信号词 Warning
危害声明 H302
警示性声明 P301 + P312 + P330
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16
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