sevenspikes.themes.common.filters
sevenspikes.themes.common.closemenu

LP-211,≥98% (HPLC)

别名:N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide, 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid 4-cyano-benzylamide, N-(4-Cyanophenyl)methyl-4-1,1′-biphenyl-2-yl-1-piperazinehexanamide

Empirical Formula (Hill Notation): C30H34N4O CAS号: 1052147-86-0 分子量: 466.62 MDL编号: MFCD22690843 PubChem化学物质编号: 329825965 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML1561
CAS号: 1052147-86-0
MDL号: MFCD22690843
增值税发票 √ 免费送货 √ 订货电话:010-68689484
¥1,456.76

说明

生化/生理作用

LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor with a Ki value of 0.58 nM at rat cloned 5-HT7 receptors, and >300-fold selectivity over the 5-HT1A receptor. The 5-HT7 receptor is involved in a variety of central nervous system functions including circadian rhythm, sleep, thermoregulation, nociception, and memory, and appears to be involved in cognitive disorders, anxiety, and depression. LP-211 has been used as a selective 5-HT7 receptor agonist in multiple models including studies as a potential therapeutic agent in models of Rett syndrome and Fragile X Syndrome.
 
LP-211 是血清素 5-HT7 受体的脑渗透选择性激动剂,对大鼠克隆的 5-HT7 受体的 Ki 值为 0.58 nM,选择性超过 5-HT1A 受体的 300 倍。 5-HT7 受体参与多种中枢神经系统功能,包括昼夜节律、睡眠、体温调节、伤害感受和记忆,并且似乎与认知障碍、焦虑和抑郁有关。 LP-211 已在多种模型中用作选择性 5-HT7 受体激动剂,包括在雷特综合征和脆性 X 综合征模型中作为潜在治疗剂的研究。
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

film

颜色

colorless

溶解性

DMSO: 5 mg/mL, clear (warmed)

储存温度

2-8°C

SMILES string

O=C(NCC1=CC=C(C#N)C=C1)CCCCCN2CCN(C3=CC=CC=C3C4=CC=CC=C4)CC2

InChI

1S/C30H34N4O/c31-23-25-14-16-26(17-15-25)24-32-30(35)13-5-2-8-18-33-19-21-34(22-20-33)29-12-7-6-11-28(29)27-9-3-1-4-10-27/h1,3-4,6-7,9-12,14-17H,2,5,8,13,18-22,24H2,(H,32,35)

InChI key

BQEDZLDNNBDKDS-UHFFFAOYSA-N

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16