LLY-507，≥97% (HPLC)

5, 25 mg in glass bottle

 

LLY-507 is a potent and selective inhibitor of SMYD2 protein lysine methyltransferase (PKMT) with an in vitro IC₅₀ <15 nM and >100-fold selectivity over other methyltransferases and other non-epigenetic targets. LY-507 has been shown to inhibit p53K370 monomethylation in cells with an IC₅₀ ~600 nM. For full characterization details, please visit the LLY-507 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

 

LLY-507 是一种有效的选择性 SMYD2 蛋白赖氨酸甲基转移酶 (PKMT) 抑制剂，其体外 IC50 <15 nM 和比其他甲基转移酶和其他非表观遗传靶点的选择性高 100 倍以上。 LY-507 已显示抑制细胞中 p53K370 单甲基化，IC50 ~600 nM。

 

LLY-507 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

 

LLY-507 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the LLY-507 probe summary on the Chemical Probes Portal website.