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LLY-507,≥97% (HPLC)

别名:5-氰基-2'-{4-[2-(3-甲基-1H-吲哚-1-基)乙基]哌嗪-1-基}-N-[3-(吡咯烷-1-基)丙基]联苯 -3-甲酰胺;5-Cyano-2′-{4-[2-(3-methyl-1H-indol-1-yl)ethyl]piperazin-1-yl}-N-[3-(pyrrolidin-1-yl)propyl]biphenyl-3-carboxamide

Empirical Formula (Hill Notation): C36H42N6O 分子量: 574.76 PubChem化学物质编号: 329825763 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML1279
增值税发票 √ 免费送货 √ 订货电话:010-68689484
€343.34

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

LLY-507 is a potent and selective inhibitor of SMYD2 protein lysine methyltransferase (PKMT) with an in vitro IC50 <15 nM and >100-fold selectivity over other methyltransferases and other non-epigenetic targets. LY-507 has been shown to inhibit p53K370 monomethylation in cells with an IC50 ~600 nM. For full characterization details, please visit the LLY-507 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
 
LLY-507 是一种有效的选择性 SMYD2 蛋白赖氨酸甲基转移酶 (PKMT) 抑制剂,其体外 IC50 <15 nM 和比其他甲基转移酶和其他非表观遗传靶点的选择性高 100 倍以上。 LY-507 已显示抑制细胞中 p53K370 单甲基化,IC50 ~600 nM。
 

特点和优势

LLY-507 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
 

其他说明

LLY-507 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the LLY-507 probe summary on the Chemical Probes Portal website.
 

属性

质量水平

100

测定

≥97% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

储存温度

2-8°C

SMILES string

CC(C1=C2C=CC=C1)=CN2CCN(CC3)CCN3C4=CC=CC=C4C5=CC(C#N)=CC(C(NCCCN6CCCC6)=O)=C5

InChI

1S/C36H42N6O/c1-28-27-42(34-11-4-2-9-32(28)34)22-19-40-17-20-41(21-18-40)35-12-5-3-10-33(35)30-23-29(26-37)24-31(25-30)36(43)38-13-8-16-39-14-6-7-15-39/h2-5,9-12,23-25,27H,6-8,13-22H2,1H3,(H,38,43)

InChI key

PNYRDVBFYVDJJI-UHFFFAOYSA-N

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16