LLY-507 is a potent and selective inhibitor of SMYD2 protein lysine methyltransferase (PKMT) with an
in vitro IC
50 <15 nM and >100-fold selectivity over other methyltransferases and other non-epigenetic targets. LY-507 has been shown to inhibit p53K370 monomethylation in cells with an IC
50 ~600 nM. For full characterization details, please visit the
LLY-507 probe summary on the Structural Genomics Consortium (SGC) website.
To learn about other SGC chemical probes for epigenetic targets, visit
sigma.com/sgc