LLY-284 is the less potent diastereomer of the potent SAM-competitive PRMT5 inhibitor LLY-283
(IC50 = 20 nM against PRMT5-catalyzed methylation of an H4R3-derived peptide substrate) and an ideal control compound for cellular studies. For characterization details of the active probe, LLY-283, please visit the LLY-283 probe summary
on the Structural Genomics Consortium (SGC) website.
LLY-283, the active probe, is available from Sigma. To learn more about and purchase LLY-283, click here
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
LLY-284 是强效 SAM 竞争性 PRMT5 抑制剂 LLY-283（针对 PRMT5 催化的 H4R3 衍生肽底物甲基化的 IC50 = 20 nM）的非对映异构体，是细胞研究的理想对照化合物。