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LLY-284,≥98% (HPLC)

别名:(2R,3R,4S,5R)-2-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((S)-hydroxy(phenyl)methyl)tetrahydrofuran-3,4-diol, LLY284, (S)-5′-phenyl-7-deazaadenosine; 6-amino-9-[(S)-5′-phenyl(ribofuranosyl)]-7-deazapurine, LLY 284

Empirical Formula (Hill Notation): C17H18N4O4 分子量: 342.35 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML1971
增值税发票 √ 免费送货 √ 订货电话:010-68689484
€580.82

说明

生化/生理作用

LLY-284 is the less potent diastereomer of the potent SAM-competitive PRMT5 inhibitor LLY-283 (IC50 = 20 nM against PRMT5-catalyzed methylation of an H4R3-derived peptide substrate) and an ideal control compound for cellular studies. For characterization details of the active probe, LLY-283, please visit the LLY-283 probe summary on the Structural Genomics Consortium (SGC) website.

LLY-283, the active probe, is available from Sigma. To learn more about and purchase LLY-283, click here.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
 
LLY-284 是强效 SAM 竞争性 PRMT5 抑制剂 LLY-283(针对 PRMT5 催化的 H4R3 衍生肽底物甲基化的 IC50 = 20 nM)的非对映异构体,是细胞研究的理想对照化合物。
 

特点和优势

LLY-284 is a negative control for LLY-283, an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
 

属性

测定

≥98% (HPLC)

形式

powder

颜色

white to beige

储存温度

2-8°C

SMILES string

O[C@@H]1[C@@H]([C@@H](O)C2=CC=CC=C2)O[C@@H](N3C(N=CN=C4N)=C4C=C3)[C@@H]1O

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16