L-甲状腺素，L-Thyroxine [T4]；powder, BioReagent, suitable for cell culture, ≥98% (HPLC)

别名：3,3′,5,5″-四碘代-L-甲状腺原氨酸；3-[4-(4-羟基-3,5-二碘苯氧基)-3,5-二碘苯基]-L-丙氨酸；3,3′,5,5″-Tetraiodo-L-thyronine, 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine, T4

线性分子式: HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H CAS号: 51-48-9 分子量: 776.87 Beilstein: 2228515 EC 号: 200-101-1 MDL编号: MFCD00002595 eCl@ss: 32190102 PubChem化学物质编号: 24899990 NACRES: NA.77

制造商品牌: 西格玛 Sigma-Aldrich

货号（SKU）: T1775

CAS号: 51-48-9

MDL号: MFCD00002595

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目录规格.SKU-Variant

100mg
1g
5g
25g

说明

一般描述

Thyroxine (T₄) is a tetraiodo derivative of the p-hydroxyphenyl ether of tyrosine,[1] which functions as growth factors or cell growth inhibitors.[2] T₄ is used to treat hypothyroidism[3] and thyroid carcinoma.[4] It regulates energy metabolism.[5]

应用

L-Thyroxine has been used to investigate its role in colorectal cancer cell lines HCT 116 (APC wild type) and HT-29 (APC mutant).[6] It has also been used to evaluate its effects on pro-inflammatory tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), angiogenic vascular endothelial growth factor (VEGF), leukocyte adhesion, intercellular adhesion molecule 1 (ICAM-1) and E-selectin in human umbilical vein endothelial cells (HUVECs).[7]

生化/生理作用

L甲状腺素 (T₄) 和三碘代-L-甲状腺原氨酸 (T₃) 为含碘激素，由甲状腺卵泡细胞中的甲状腺球蛋白制备。这些激素对代谢率的刺激以及对生长发展的调节似乎归因于它们对 DNA 转录的作用，进而影响蛋白质的合成。

制备说明

For long term storage, keep stock solutions at -20° in working aliquots and avoid repeated freeze/thaw cycles. Solutions stored at 2-8 °C are stable for up to 30 days.

重悬

To prepare 20 μg/ml stock solution, dissolve in 50 ml sterile culture medium per mg thyroxine.

属性

生物来源

synthetic

质量水平

200

产品线

BioReagent

测定

≥98% (HPLC)

形式

powder

效能

5-50 ng/mL

technique(s)

cell culture | mammalian: suitable

mp

223 °C (dec.) (lit.)

溶解性

4 M NH₄OH in methanol: 50 mg/mL, clear to hazy, yellow

运输

ambient

储存温度

room temp

SMILES string

N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1

InChI key

XUIIKFGFIJCVMT-LBPRGKRZSA-N

Gene Information

human ... THRA(7067) , THRB(7068) , TTR(7276)
mouse ... Cnr2(12802)
rat ... Cnr1(25248)

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格

属性名称	属性值
储存温度 Storage temp.	-20°C低温冷冻
全球实时库存 Availability √	美国St. Louis ≥ 50 \| 欧洲Eur. ≥ 12 \| 東京Tokyo ≥ 20 \| 香港与北京 ≥ 50

商品标签 [tags]

l-甲状腺素 (3)
,
t4 (5)

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