KYA1797K potassium salt；≥98% (HPLC)

图片 KYA1797K potassium salt；≥98% (HPLC)
别名：KYA1797K钾盐；KYA-1797K；(5Z)-5-[[5-(4-硝基苯基)-2-呋喃基]亚甲基]-4-氧代-2-硫代-3-噻唑烷丙酸钾盐；(Z)-3-(5-((5-(4-硝基苯基)呋喃-2-亚甲基)-4-氧代-2-硫代噻唑烷-3-基)丙酸钾盐；(5Z)-5-[[5-(4-Nitrophenyl)-2-furanyl]methylene]-4-oxo-2-thioxo-3-thiazolidinepropanoic acid potassium salt；(Z)-3-(5-((5-(4-nitrophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)propanoic acid potassium salt, KYA1797 potassium salt

Empirical Formula (Hill Notation): C17H11KN2O6S2 CAS号: 1956356-56-1 分子量: 442.51
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: SML1831
CAS号: 1956356-56-1
MDL号: MFCD30718585
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说明

生化/生理作用

KYA1797K is an inhibitor of both Wnt/β-catenin and Ras pathways. It binds to the axin regulators of the G-protein signaling (RGS) domain enhancing formation of the β-catenin destruction complex and inducing activation GSK3β, which results in phosphorylation and subsequent degradation of both β-catenin and K-Ras. KYA1797K was show to suppress tumor growth and progression in mouse xenografts of CRC cells that had APC and K-Ras mutations.
 
 

属性

检测方案

≥98% (HPLC)

形式

powder

颜色

orange to dark red

溶解性

DMSO: 2 mg/mL, clear (warmed)

储存温度

2-8°C

SMILES string

[O-]C(CCN1C(/C(SC1=S)=C/C2=CC=C(C3=CC=C([N+]([O-])=O)C=C3)O2)=O)=O.[K+]

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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