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KYA1797K potassium salt,≥98% (HPLC)

别名:KYA1797K钾盐;KYA-1797K;(5Z)-5-[[5-(4-Nitrophenyl)-2-furanyl]methylene]-4-oxo-2-thioxo-3-thiazolidinepropanoic acid potassium salt, (Z)-3-(5-((5-(4-nitrophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)propanoic acid potassium salt, KYA1797 potassium salt

CAS号 1956356-56-1 经验分子式(希尔表示法) C17H11KN2O6S2 分子量 442.51
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML1831
CAS号: 1956356-56-1
MDL号: MFCD30718585
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¥1,164.07

产品描述

一种有效的选择性的Wnt/β-catenin 抑制剂,IC50:0.75μM。

包装

5, 25 mg in glass bottle

Biochem/physiol Actions

KYA1797K is an inhibitor of both Wnt/β-catenin and Ras pathways. It binds to the axin regulators of the G-protein signaling (RGS) domain enhancing formation of the β-catenin destruction complex and inducing activation GSK3β, which results in phosphorylation and subsequent degradation of both β-catenin and K-Ras. KYA1797K was show to suppress tumor growth and progression in mouse xenografts of CRC cells that had APC and K-Ras mutations.

KYA1797K是Wnt /β-catenin和Ras途径的抑制剂。 它与G蛋白信号(RGS)域的毒素调节剂结合,增强β-连环蛋白破坏复合物的形成并诱导GSK3β活化,从而导致β-连环蛋白和K-Ras磷酸化并随后降解。 已显示KYA1797K可抑制具有APC和K-Ras突变的CRC细胞的小鼠异种移植物中的肿瘤生长和进展。

性质

Quality Level  100
assay  ≥98% (HPLC)
form  powder
color  orange to dark red
solubility  DMSO: 2 mg/mL, clear (warmed)
storage temp.  2-8°C
SMILES string  [O-]C(CCN1C(/C(SC1=S)=C/C2=CC=C(C3=CC=C([N+]([O-])=O)C=C3)O2)=O)=O.[K+]


安全信息

RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16