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Ki8751,[VEGFR2 Kinase Inhibitor VI];≥97% (HPLC)

别名:N-(2,4-Difluorophenyl)-Nʹ-(4-(6,7-dimethoxy-4-quinolyloxy)-2-fluorophenyl)urea, Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor VI, VEGFR Tyrosine Kinase Inhibitor XXIV, VEGFR2 Kinase Inhibitor VI, 1-(2,4-二氟苯基)-3-(4-((6,7-二甲氧基喹啉-4-基)氧基)-2-氟苯基)脲

CAS号 228559-41-9 经验分子式(希尔表示法) C24H18F3N3O4 分子量 469.41
货号(SKU): 676484
CAS号: 228559-41-9
MDL号: MFCD09971092
增值税发票 √ 免费送货 √ 订货电话:010-68689484
¥3,048.19

产品描述

一种VEGFR2抑制剂,IC50:0.9nM。对c-kit、PDGFRα和FGFR-2有抑制作用(IC50值在40-170nm之间)。

General description

A cell-permeable quinolyloxyphenyl-urea compound that acts as a VEGFR-2-selective inhibitior in both cell-based (IC50 = 0.9 nM in VEGF-induced receptor phosphorylation) and cell-free (IC50 = 4.0 nM in kinase reactions) assays. It inhibits c-Kit, PDGFRα, and FGFR-2 only at much higher concentrations (IC50 = 40, 67, and 170 nM, respectively, in cell-based assays), while exhibiting no effect against eight other commonly studied receptor and non-receptor kinases even at concentrations as high as 10 µM. Effectively blocks VEGF-dependent, but not VEGF-independent, cell proliferation in vitro and tumor growth in mice and rats (5 to 20 mg/kg, daily p.o.) in vivo.

包装

5 mg in Plastic ampoule

Packaged under inert gas

Warning

Toxicity: Regulatory Review (Z)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Kubo, K., et al. 2005. J. Med. Chem.48, 1359.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

性质

Quality Level  100
assay  ≥97% (HPLC)
form  solid
mfr. no.  Calbiochem®
storage condition  OK to freeze
 protect from light
storage conditions  +2C to +8C
color  off-white
solubility  DMSO: 50 mg/mL
shipped in  ambient


安全信息

安全声明 (欧洲) 22-24/25-36/37/39
WGK德国 WGK 1
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 55 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 8 | 香港与北京 ≥ 10