JNJ7777120，≥98% (HPLC)

图片 JNJ7777120，≥98% (HPLC)
别名：1-[(5-氯-1H-吲哚-2-基)羰基]-4-甲基-哌嗪；1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methyl-piperazine；(5-氯-1H-吲哚-2-基)(4-甲基哌嗪-1-基)甲酮

Empirical Formula (Hill Notation): C14H16N3OCl CAS号: 459168-41-3 分子量: 277.75 MDL编号: MFCD04343337 PubChem化学物质编号: 329815408 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: J3770
CAS号: 459168-41-3
MDL号: MFCD04343337
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说明

应用

JNJ7777120 has been used as a histamine-4 receptor antagonist:
  • to study its effects on the pro-inflammatory microglia in rats[1]
  • to study its effects on the Parkinson′s-like pathology in rat brain[2]
  • to study its effects on the histamine receptor interaction in periodontal ligament fibroblasts (PDLF)[3]

生化/生理作用

JNJ7777120 may exhibit neuroprotective effects against ischemic brain damage.[4] It acts as an anti-inflammatory agent to treat inflammatory diseases. JNJ7777120 is observed to reduce colonic injury, cytokine production, and neutrophil infiltration.[5]
JNJ7777120 is a potent, selective non-imidazole H4 histamine receptor antagonist.
 

特点和优势

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 
 

属性

质量水平

100

检测方案

≥98% (HPLC)

形式

solid

颜色

white to off-white

溶解性

DMSO: >20 mg/mL
H2O: insoluble

创始人

Johnson & Johnson

储存温度

room temp

SMILES string

CN1CCN(CC1)C(=O)c2cc3cc(Cl)ccc3[nH]2

InChI

1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3

InChI key

HUQJRYMLJBBEDO-UHFFFAOYSA-N

 

安全信息

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315 - H319 - H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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