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ISOX-INACT,≥98% (HPLC)

别名:4-(2-(5-(3,5-二甲基异恶唑-4-基)-2-(4-甲氧基苯乙基)-4,6-二甲基-1H苯并[d]咪唑-1-基)乙基)吗啉;4-(2-(5-(3,5-Dimethylisoxazol-4-yl)-2-(4-methoxyphenethyl)-4,6-dimethyl-1Hbenzo[d]imidazol-1-yl)ethyl)morpholine

Empirical Formula (Hill Notation): C29H36N4O3 分子量: 488.62 PubChem化学物质编号: 329823843 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0332
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$354.21

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

ISOX-INACT is an inactive control probe for the highly-selective inhibitor of the bromodomain of CREB binding protein (CBP BRD) PF-CBP1.
CBP BRD (CREB binding protein bromodomain) inhibition serves as an effective therapeutic target for Parkinson′s disease. The inhibition is followed by negative regulation of a number of macrophage inflammatory genes. It also downregulates G-protein signaling 4 mRNA.
 
ISOX-INACT 是一种无活性对照探针,用于 CREB 结合蛋白 (CBP BRD) PF-CBP1 溴结构域的高选择性抑制剂。
CBP BRD(CREB 结合蛋白溴结构域)抑制是帕金森病的有效治疗靶点。 抑制之后是许多巨噬细胞炎症基因的负调节。 它还下调 G 蛋白信号 4 mRNA。
 

其他说明

This compound was developed by Pfizer for Gene Regulation research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

创始人

Pfizer

储存温度

room temp

SMILES string

CC1=NOC(C)=C1C2=C(C)C(N=C(CCC3=CC=C(OC)C=C3)N4CCN5CCOCC5)=C4C=C2C

InChI

1S/C29H36N4O3/c1-19-18-25-29(20(2)27(19)28-21(3)31-36-22(28)4)30-26(11-8-23-6-9-24(34-5)10-7-23)33(25)13-12-32-14-16-35-17-15-32/h6-7,9-10,18H,8,11-17H2,1-5H3

InChI key

FTOHXUPHICJSCR-UHFFFAOYSA-N

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16