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IOX1,≥97% (HPLC)

别名:5-羧基-8-羟基喹啉;8-羟基-5-喹啉羧酸;5-Carboxy-8-hydroxyquinoline;8-Hydroxy-5-quinolinecarboxylic acid

Empirical Formula (Hill Notation): C10H7NO3 CAS号: 5852-78-8 分子量: 189.17 MDL编号: MFCD18417145 PubChem化学物质编号: 329825131 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML0067
CAS号: 5852-78-8
MDL号: MFCD18417145
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¥22,107

说明

应用

IOX1 has been used:
  • To eliminate viral latency in latent viruses in order to sensitize the viral infections to antiviral therapy.
  • In histone lysine demethylase 4A (KDM4A) inhibition, to serve as a unique strategy to decrease hypoxia-inducible factors signalling.
  • to restore oncogene-induced senescence in wild-type mouse embryo fibroblasts.

包装

5, 25 mg in glass bottle
 

生化/生理作用

IOX1 (5-Carboxy-8-hydroxyquinoline) is a broad spectrum inhibitor of 2-oxoglutarate (2OG) oxygenases, including Jumonji C domain (JmjC) demethylases. It is useful for the study of histone demethylation and hypoxic sensing and results in translocation of active site iron on the 2OG oxygenases. For full characterization details, please visit the IOX1 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
IOX1 has an IC50 value as 200nM. IOX1 might be used in the treatment of β-thalassemia by α-globin downregulation.
 
IOX1 (5-Carboxy-8-hydroxyquinoline) 是 2-酮戊二酸 (2OG) 加氧酶的广谱抑制剂,包括 Jumonji C 结构域 (JmjC) 脱甲基酶。 它可用于研究组蛋白去甲基化和缺氧传感,并导致 2OG 加氧酶上活性位点铁的易位。
 

特点和优势

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
IOX1 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
 

属性

测定

≥97% (HPLC)

形式

powder

颜色

white to brown

溶解性

DMSO: 10 mg/mL, clear

储存温度

2-8°C

SMILES string

OC(=O)c1ccc(O)c2ncccc12

InChI

1S/C10H7NO3/c12-8-4-3-7(10(13)14)6-2-1-5-11-9(6)8/h1-5,12H,(H,13,14)

InChI key

JGRPKOGHYBAVMW-UHFFFAOYSA-N

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16