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Interleukin-7 human,[人IL-7, IL7, LP-1];≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Recombinant Human IL-7/IL7;MDL number MFCD00163948 NACRES NA.32
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): I5896
MDL号: MFCD00163948
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¥2,638.28

产品描述

General description

The interleukin-7 human (IL-7) gene is mapped to human chromosome 8q21.13.[5] It is a non-hematopoietic cell-derived cytokine.[3] IL-7 is majorly produced by the fibroblastic stromal cells, dendritic cells, thymus epithelial cells and skin keratinocytes.[3] Structurally, IL-7 takes up an up-up-down-down 4-helix bundle topology and has two crossover loops.[1]

Biochem/physiol Actions

IL-7 helix A is crucial for its interaction with the interleukin-7 human receptor (IL-7Rα). It is reported to enhance immunity during viral infections and may be useful in cancer immunotherapy.[3] Mutation in the IL-7 gene is implicated in CD4+ T-cell lymphopenia.[8]

Interleukin-7 is a lymphoid cell growth factor which affects pre-B, pro-B and early T cells. It was first isolated by Namen in 1988. IL-7 has a number of known activities. It supports the growth of early B cells from long-term lymphoid bone marrow cultures. It is mitogenic for thymocytes and co-mitogenic with PHA and Con A. IL-7 also stimulates the proliferation of CD4/CD8 cells. The proliferative response of thymocytes to IL-7 is not affected by antibodies to the T cell growth factors such as IL-2, IL-4, and IL-6. Mature T cells respond to IL-7 and Con A, but not to IL-7 alone. Antibodies against IL-2 affect its activity, suggesting that it functions through IL-2 production. Human natural IL-7 is 25 kDa glycoprotein that has 6 cysteine residues which are important for biological activity. Human and mouse IL-7 have 60% amino acid sequence homology.

Lymphoid cell growth factor which affects pre-B, pro-B and early T cells; supports the growth of early B cells and is mitogenic for thymocytes and co-mitogenic with PHA and Con A; stimulates the proliferation of CD4/CD8 cells.

Physical form

Lyophilized from a 0.2 μm filtered solution in 10 mM acetic acid containing 250 μg bovine serum albumin.

性质

Quality Level  200
biological source  human
recombinant  expressed in E. coli
assay  ≥98% (SDS-PAGE)
form  lyophilized powder
potency  ≤0.500 ng/mL EC50
mol wt  25 kDa
packaging  pkg of 5 μg
storage condition  avoid repeated freeze/thaw cycles
application(s)  cell culture | mammalian: suitable
impurities  endotoxin, tested
color  white
solubility  water: soluble 0.005-0.010 mL
UniProt accession no.  P13232
storage temp.  −20°C
Gene Information  human ... IL7(3574)


安全信息

个人防护装备 EyeshieldsGlovestype N95 (US)
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 60 | 欧洲Eur. ≥ 21 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 10