Interleukin-5 human,[人IL-5, IL5];recombinant, expressed in baculovirus infected Sf21 cells, ≥97% (SDS-PAGE), lyophilized powder, suitable for cell culture

人白细胞介素5;Recombinant Human IL-5;Interleukin-5;IL-5;B-cell differentiation factor I;Eosinophil differentiation factor;T-cell replacing factor;TRF;MDL number MFCD00163946 NACRES NA.32
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): I5273
MDL号: MFCD00163946
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Biochem/physiol Actions

IL-5 (interleukin-5) is a maturation and differentiation factor for eosinophils. Thus, it is associated with allergy and related disorders.[1] IL-5 association with its receptor causes activation of MEK/ERK (mitogen activated protein kinase kinase/extracellular-regulated kinase), p38 MAPK (mitogen activated protein kinase) and JAK/STAT (Janus kinase/signal transducer and activator of transcription) pathways.[2]

Interleukin-5 is a product of activated T lymphocytes and exhibits activity on eosinophils, B cells and thymocytes. Synonyms or biological activities attributed to IL-5 include: EDF (eosinophil differentiating factor), BCGF-II (B cell growth factor-II), TRF (T cell replacing factor), IgA-EF (IgA enhancing factor) and EO-CSF (eosinophil colony stimulating factor). Natural IL-5 is a 45-50 kDa dimeric glycoprotein, although glycosylation is not required for activity. Human and mouse IL-5 exhibit homology at the nucleotide and amino acid levels and show species cross-reactivity.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.1 mg bovine serum albumin.


Quality Level  200
biological source  human
recombinant  expressed in baculovirus infected Sf21 cells
assay  ≥97% (SDS-PAGE)
form  lyophilized powder
potency  0.1-0.5 ng/mL EC50
mol wt  32-34 kDa
packaging  pkg of 5 μg
concentration  0.5-10 ng/mL
application(s)  cell culture | mammalian: suitable
impurities  endotoxin, tested
UniProt accession no.  P05113
storage temp.  −20°C
Gene Information  human ... IL5(3567)


个人防护装备 EyeshieldsGlovestype N95 (US)
RIDADR NONH for all modes of transport
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 60 | 欧洲Eur. ≥ 21 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 10