IL-5 (interleukin-5) is a maturation and differentiation factor for eosinophils. Thus, it is associated with allergy and related disorders. IL-5 association with its receptor causes activation of MEK/ERK (mitogen activated protein kinase kinase/extracellular-regulated kinase), p38 MAPK (mitogen activated protein kinase) and JAK/STAT (Janus kinase/signal transducer and activator of transcription) pathways.
Interleukin-5 is a product of activated T lymphocytes and exhibits activity on eosinophils, B cells and thymocytes. Synonyms or biological activities attributed to IL-5 include: EDF (eosinophil differentiating factor), BCGF-II (B cell growth factor-II), TRF (T cell replacing factor), IgA-EF (IgA enhancing factor) and EO-CSF (eosinophil colony stimulating factor). Natural IL-5 is a 45-50 kDa dimeric glycoprotein, although glycosylation is not required for activity. Human and mouse IL-5 exhibit homology at the nucleotide and amino acid levels and show species cross-reactivity.
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.1 mg bovine serum albumin.
|Quality Level ||200|
|biological source ||human|
|recombinant ||expressed in baculovirus infected Sf21 cells|
|assay ||≥97% (SDS-PAGE)|
|form ||lyophilized powder|
|potency ||0.1-0.5 ng/mL EC50|
|mol wt ||32-34 kDa|
|packaging ||pkg of 5 μg|
|concentration ||0.5-10 ng/mL|
|application(s) ||cell culture | mammalian: suitable|
|impurities ||endotoxin, tested|
|UniProt accession no. ||P05113|
|storage temp. ||−20°C|
|Gene Information ||human ... IL5(3567)|
RIDADR NONH for all modes of transport