Interleukin-12 human,[人IL-12, IL12];≥97% (SDS-PAGE and N-terminal analysis), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture

人白介素12;人白细胞介素12;MDL number MFCD00212975 NACRES NA.32
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): I2276
MDL号: MFCD00212975
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Biochem/physiol Actions

Interleukin-12 (IL-12) was identified as a factor secreted by human Epstein-Barr (EBV)-transformed B cell lines. IL-12, or Natural Killer Cell Stimulatory Factor (NKSF), is a 75 kDa disulfide-linked heterodimer of a 35 kDa subunit and 40 kDa subunit. IL-12 is produced predominantly by monocytes and NK cells and induces T cells and NK cells to produce IFN-γ. Human IL-12 is not active on mouse cells, but murine IL-12 is active on both murine and human lymphocytes. The biological activity of recombinant human IL-12 was measured by its ability to stimulate the proliferation of PHA-activated human T lymphoblasts. IL-12 has anti-angiogenic properties.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.25 mg bovine serum albumin.


Quality Level  200
biological source  human
recombinant  expressed in baculovirus infected Sf21 cells
assay  ≥97% (SDS-PAGE and N-terminal analysis)
form  lyophilized powder
potency  0.01-0.05 ng/mL ED50
mol wt  glycoprotein 75 kDa
packaging  pkg of 5 μg
application(s)  cell culture | mammalian: suitable
impurities  endotoxin, tested
UniProt accession no.  P29459,
storage temp.  −20°C
Gene Information  human ... IL12A(3592), IL12B(3593)


个人防护装备 EyeshieldsGlovestype N95 (US)
RIDADR NONH for all modes of transport
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16