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Interleukin-10 human,[人IL-10, IL10];≥97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture

Recombin human IL10 protein;CSIF, IL 10, IL10, IL-10, IL10A, interleukin 10, TGIF;MDL number MFCD00131400 NACRES NA.32
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): I9276
MDL号: MFCD00131400
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¥3,132.12

产品描述

Application

Interleukin-10 (IL-10) human has been used to study the effect of IL-10 on cartilage proteoglycan turnover.[1] It has been used as an antigen to analyse the reactivity patterns of autoantibodies in healthy humans and humans suffering from type 1 diabetes mellitus.[2]

Biochem/physiol Actions

IL-10 is an important regulator of the functions of lymphoid and myeloid cells. IL-10 can block the activation of cytokine synthesis and several accessory functions of macrophages. Human and mouse IL-10 share a 73% sequence homology. However, human IL-10 acts on both human and mouse target cells, while mouse IL-10 has species-specific activity. In mouse, the cellular sources of IL-10 consist of Th2 cells, activated fetal thymocytes, macrophages, keratinocytes, LY-1+ (CD5+), and normal B cells. In human, the cellular sources of IL-10 consist of CD4+ T cells and T cell clones, thymocytes, B cells, B cell lymphomas, macrophages, mast cell lines and keratinocytes. IL-10 stimulates the growth of stem cells, mast cells and thymocytes. IL-10 enhances cytotoxic T cell development, and co-stimulates B cell differentiation and Ig secretion. IL-10 regulates angiogenesis by inducing the cell-type dependent expression of either angiogenic or angiostatic factors.

Interleukin-10 regulates lymphoid and myeloid cell functions. It blocks the activation of cytokine synthesis and several accessory functions of macrophages. IL-10 enhances cytotoxic T cell development and co-stimulates B cell differentiation and Ig secretion. IL-10 regulates angiogenesis by inducing cell-type dependent expression of either angiogenic or angiostatic factors.

Physical form

Lyophilized from a 0.2 μm filtered solution of phosphate buffered saline, pH 7.4, containing 50 μg bovine serum albumin/μg IL-10

性质

Quality Level  200
biological source  human
recombinant  expressed in baculovirus infected Sf21 cells
assay  ≥97% (SDS-PAGE)
form  lyophilized powder
potency  0.1-0.5 ng/mL EC50
mol wt  18 kDa
packaging  pkg of 5 μg
application(s)  cell culture | mammalian: suitable
impurities  endotoxin, tested
UniProt accession no.  P22301
storage temp.  −20°C
Gene Information  human ... IL10(3586)


安全信息

个人防护装备 EyeshieldsGlovestype N95 (US)
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 60 | 欧洲Eur. ≥ 21 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 10