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IM-12,≥98% (HPLC)

别名:IM12;3-((4-氟苯乙基)氨基)-1-甲基-4-(2-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮;3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

CAS号 1129669-05-1 经验分子式(希尔表示法) C22H20FN3O2 分子量 377.41 MDL number MFCD20527313 PubChem Substance ID 329825145 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML0084
CAS号: 1129669-05-1
MDL号: MFCD20527313
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$267.66

产品描述

一种丝氨酸蛋白激酶(GSK-3β)抑制剂。

包装

5, 25 mg in glass bottle

Biochem/physiol Actions

IM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3β (GSK-3β) inhibitor, activating downstream components of canonical Wnt signaling. IM-12 significantly increased β-catenin levels. When used to treat human neural progenitor cells, IM-12 promoted neuronal differentiation resulting in an increase of neuronal cells. It has an IC50 of 53 nM in an in vitro binding assay, compared with 92 nM for SB-216763 in the same assay condition.

IM-12是一种细胞可渗透的吲哚基马来酰亚胺,可作为糖原合酶激酶3β(GSK-3β)抑制剂,激活经典Wnt信号传导的下游成分。 IM-12显着增加了β-catenin的水平。 当用于治疗人类神经祖细胞时,IM-12促进神经元分化,导致神经元细胞增加。 在体外结合试验中,IC50为53 nM,而在相同试验条件下,SB-216763的IC50为92 nM。

性质

Quality Level  100
assay  ≥98% (HPLC)
form  powder
storage condition  desiccated
color  yellow-orange
solubility  DMSO: ≥9 mg/mL
storage temp.  2-8°C
SMILES string  CN1C(=O)C(NCCc2ccc(F)cc2)=C(C1=O)c3c(C)[nH]c4ccccc34
InChI  1S/C22H20FN3O2/c1-13-18(16-5-3-4-6-17(16)25-13)19-20(22(28)26(2)21(19)27)24-12-11-14-7-9-15(23)10-8-14/h3-10,24-25H,11-12H2,1-2H3
InChI key  ZKJAZFUFPPSFCO-UHFFFAOYSA-N


安全信息

危害码 (欧洲) Xn
风险声明 (欧洲) 22
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32