sevenspikes.themes.common.filters
sevenspikes.themes.common.closemenu

IL-7 human,[人IL-7, IL7, LP-1];Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Lymphopoietin 1 (LP-1), pre-B cell factor;Recombinant Human IL-7/IL7;MDL number MFCD00163948 NACRES NA.32
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SRP3266
增值税发票 √ 免费送货 √ 订货电话:010-68689484
¥4,210.84

产品描述

General description

IL7 (interleukin 7) was first identified in 1988 in a bone marrow culture as a factor that facilitated murine B cell precursors growth. It is a cytokine produced by non-lymphoid cells in lymphoid organs. In humans, it is also produced by keratinocytes, peripheral blood dendritic cells,follicular dendritic cells, intestinal epithelial cells, hepatic tissue, endothelial cells, smooth muscle cells and fibroblasts. IL7 gene is localized to human chromosome 8q12-q13. It is a glycoprotein with a four a-helix structure with a hydrophobic core.[1] Recombinant human IL-7 is a 17.4 kDa protein containing 153 amino acid residues.

Biochem/physiol Actions

IL7 (interleukin 7) is crucial for lymphocyte survival and development. It is required for the survival, proliferation and the rearrangement of certain TCR (T cell receptor) genes in earliest thymus stem cells. During later stages, in thymus, it is essential for the positive selection of CD8 cells. IL7 is also essential for the survival and homeostatic proliferation of mature T cells which have left the thymus.[1] In patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT), increased IL-7 plasma levels in the early post-transplant period is linked with suppressed T cell counts and elevated risks of acute graft-versus-host disease (aGVHD) and mortality.[2] IL7 shows varied tear expression levels during different stages of Graves′ ophthalmopathy (GO), and thus, might be implicated in the pathogenesis of GO.[3]

Physical form

Lyophilized from 10 mM Acetic Acid.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

性质

biological source  human
recombinant  expressed in E. coli
assay  ≥98% (HPLC)
 ≥98% (SDS-PAGE)
form  lyophilized
potency  ≤0.5 ng/mL ED50
mol wt  17.4 kDa
packaging  pkg of 10 μg
impurities  <0.1 EU/μg endotoxin, tested
color  white to off-white
UniProt accession no.  P13232
shipped in  wet ice
storage temp.  −20°C
Gene Information  human ... IL7(3574)


安全信息

个人防护装备 EyeshieldsGlovestype N95 (US)
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 60 | 欧洲Eur. ≥ 21 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 10