IL-5 is a hematopoietic growth factor that stimulates the proliferation and activation of eosinophils. Produced by mast cells, T cells, and eosinophils, IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. Elevated levels of IL-5 lead to Eosinophilia, which may result in the induction of asthma and other allergic diseases. Human and murine IL-5 is cross-species reactive. Recombinant human IL-5 is a 26.0 kDa disulfide-linked homodimeric protein containing two 116 amino acid chains.
IL-5 is a hematopoietic growth factor that stimulates the proliferation and activation of eosinophils. Recombinant human IL-5 is a 26.0 kDa disulfide-linked homodimeric protein containing two 116 amino acid chains.
MIPTEIPTSA LVKETLALLS THRTLLIANE TLRIPVPVHK NHQLCTEEIF QGIGTLESQT VQGGTVERLF KNLSLIKKYI DGQKKKCGEE RRRVNQFLDY LQEFLGVMNT EWIIES
Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium glycinate, pH 8.5
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
|biological source ||human|
|recombinant ||expressed in E. coli|
|assay ||≥98% (HPLC)|
| ||≥98% (SDS-PAGE)|
|potency ||≤0.25 ng/mL ED50|
|mol wt ||26.0 kDa|
|packaging ||pkg of 10 μg|
|application(s) ||cell culture | mammalian: suitable|
|impurities ||<0.1 EU/μg endotoxin, tested|
|color ||off-white to yellow|
|UniProt accession no. ||P05113|
|shipped in ||wet ice|
|storage temp. ||−20°C|
|Gene Information ||human ... IL5(3567)|
RIDADR NONH for all modes of transport