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GSK9311,≥98% (HPLC)

别名:N-[2,3-Dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-N-ethyl-2-methoxybenzamide, (R)-N-(1,3-Dimethyl-6-(2-methylpiperazin-1-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-N-ethyl-2-methoxybenzamide

Empirical Formula (Hill Notation): C24H31N5O3 CAS号: 1923851-49-3 分子量: 437.53 MDL编号: MFCD31382186 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML1984
CAS号: 1923851-49-3
MDL号: MFCD31382186
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$256.48

说明

生化/生理作用

GSK9311 is a negative control for the SGC epigenetic probe GSK6853. GSK9311 exhibits 125- and 185-fold reduced potency than its structural analog GSK6853 toward BRPF1 in cell-free and cell-based assays (pIC50 = 6.0/GSK9311 vs. 8.1/GSK6853 in ligand competition binding assay by TR-FRET; IC50 = 3.7 μM/GSK9311 vs. 20 nM/GSK6853 against NanoLuc-BRPF1 bromodomain interaction with Histone H3.3-HaloTag in HEK293 cells), and therefore serves as a good inactive control compound in BRPF1 inhibition studies employing GSK6853. For characterization details of the active probe, GSK6853, please visit the GSK6853 probe summary on the Structural Genomics Consortium (SGC) website.

GSK6853, the active probe, is available from Sigma. To learn more about and purchase GSK6853, click here.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
 
GSK9311 是 SGC 表观遗传探针 GSK6853 的阴性对照。 GSK9311 在无细胞和基于细胞的试验中对 BRPF1 的效力比其结构类似物 GSK6853 降低 125 和 185 倍(pIC50 = 6.0/GSK9311 vs. 8.1/GSK6853 在 TR-FRET 配体竞争结合试验中;IC50 = 3.7 μM/GSK9311 与 20 nM/GSK6853 对抗 NanoLuc-BRPF1 溴结构域与 HEK293 细胞中组蛋白 H3.3-HaloTag 的相互作用),因此在使用 GSK6853 的 BRPF1 抑制研究中可作为良好的无活性对照化合物。
 

特点和优势

GSK9311 is the negative control for GSK6853, an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
 

属性

测定

≥98% (HPLC)

形式

powder

旋光性

[α]/D 90 to 100°, c = 0.3 in methanol

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear (warmed)

储存温度

−20°C

SMILES string

O=C1N(C)C2=CC(N3CCNC[C@H]3C)=C(N(CC)C(C4=C(OC)C=CC=C4)=O)C=C2N1C

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16