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GRN-529,≥97% (HPLC)

别名:[4-(二氟甲氧基)-3-[2-(2-吡啶基)乙炔基]苯基](5,7-二氢-6H-吡咯并[3,4-b]吡啶-6-基)-甲酮;[4-(Difluoromethoxy)-3-[2-(2-pyridinyl)ethynyl]phenyl](5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-methanone

Empirical Formula (Hill Notation): C22H15F2N3O2 CAS号: 1253291-12-1 分子量: 391.37 MDL编号: MFCD28160551 PubChem化学物质编号: 329823817
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0293
CAS号: 1253291-12-1
MDL号: MFCD28160551
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$354.21

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

GRN-529 is a brain penetrant, potent and selective negative allosteric modulator of the mGluR5 receptor (metabotropic glutamate receptor subtype 5) with an IC50 of 3.1 nM and >1000-fold selectivity vs mGluR1. GRN-529 was shown to alleviate multiple diagnostic behavioral symptoms of autism in BTBR and C58 mice models.
 
GRN-529 是 mGluR5 受体(代谢型谷氨酸受体亚型 5)的脑渗透、有效和选择性负变构调节剂,IC50 为 3.1 nM,选择性比 mGluR1 高 1000 倍。 GRN-529 被证明可以减轻 BTBR 和 C58 小鼠模型中自闭症的多种诊断行为症状。
 

其他说明

This compound was developed by Pfizer for Neuroscience research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥97% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

创始人

Pfizer

储存温度

room temp

SMILES string

FC(F)OC1=C(C#CC2=NC=CC=C2)C=C(C(N3CC(N=CC=C4)=C4C3)=O)C=C1

InChI

1S/C22H15F2N3O2/c23-22(24)29-20-9-7-16(12-15(20)6-8-18-5-1-2-10-25-18)21(28)27-13-17-4-3-11-26-19(17)14-27/h1-5,7,9-12,22H,13-14H2

InChI key

JITMSIRHBAVREW-UHFFFAOYSA-N

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16