GRN-529，≥97% (HPLC)

别名：[4-(二氟甲氧基)-3-[2-(2-吡啶基)乙炔基]苯基](5,7-二氢-6H-吡咯并[3,4-b]吡啶-6-基)-甲酮；[4-(Difluoromethoxy)-3-[2-(2-pyridinyl)ethynyl]phenyl](5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-methanone

Empirical Formula (Hill Notation): C22H15F2N3O2 CAS号: 1253291-12-1 分子量: 391.37 MDL编号: MFCD28160551 PubChem化学物质编号: 329823817

制造商品牌: 西格玛 Sigma-Aldrich

货号（SKU）: PZ0293

CAS号: 1253291-12-1

MDL号: MFCD28160551

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目录价.SKU-Variant

10mg
50mg [+¥10,540.00]

¥5,760.00

数量:

说明

生化/生理作用

GRN-529 is a brain penetrant, potent and selective negative allosteric modulator of the mGluR5 receptor (metabotropic glutamate receptor subtype 5) with an IC₅₀ of 3.1 nM and >1000-fold selectivity vs mGluR1. GRN-529 was shown to alleviate multiple diagnostic behavioral symptoms of autism in BTBR and C58 mice models.

其他说明

This compound was developed by Pfizer for Neuroscience research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

法律信息

Sold for research purposes under agreement from Pfizer Inc.

Pfizer is a registered trademark of Pfizer, Inc.

属性

质量水平

100

测定

≥97% (HPLC)

形式

powder

mfr. no.

Pfizer^®

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

创始人

Pfizer

储存温度

room temp

SMILES string

FC(F)OC1=C(C#CC2=NC=CC=C2)C=C(C(N3CC(N=CC=C4)=C4C3)=O)C=C1

InChI

1S/C22H15F2N3O2/c23-22(24)29-20-9-7-16(12-15(20)6-8-18-5-1-2-10-25-18)21(28)27-13-17-4-3-11-26-19(17)14-27/h1-5,7,9-12,22H,13-14H2

InChI key

JITMSIRHBAVREW-UHFFFAOYSA-N

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格

属性名称	属性值
储存温度 Storage temp.	常温阴凉避光
全球实时库存 Availability √	美国St. Louis ≥ 20 \| 欧洲Eur. ≥ 16 \| 東京Tokyo ≥ 5 \| 香港与北京 ≥ 20