sevenspikes.themes.common.filters
sevenspikes.themes.common.closemenu

GNF-2,≥98% (HPLC), solid

别名:Bcr-abl Inhibitor;3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide

CAS号 778270-11-4 经验分子式(希尔表示法) C18H13F3N4O2 分子量 374.32 MDL number MFCD09265253 PubChem Substance ID 24724498 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): G9420
CAS号: 778270-11-4
MDL号: MFCD09265253
增值税发票 √ 免费送货 √ 订货电话:010-68689484
¥2,374.01

产品描述

一种Bcr-Abl抑制剂。

包装

5, 25 mg in glass bottle

Biochem/physiol Actions

GNF-2 belongs to a new class of Bcr-abl inhibitors. GNF-2 appears to bind to the myristoyl binding pocket, an allosteric site distant from the active site, stabilizing the inactive form of the kinase. It inhibits Bcr-abl phosphorylation with an IC50 of 267 nM, but does not inhibit a panel of 63 other kinases, including native c-Abl, and shows complete lack of toxicity towards cells not expressing Bcr-Abl. GNF-2 shows great potential for a new class of inhibitor to study Bcr-abl activity and to treat resistant Chronic myelogenous leukemia (CML), which is caused the Bcr-Abl oncoprotein.

GNF-2属于一类新的Bcr-abl抑制剂。 GNF-2似乎与肉豆蔻酰基结合袋结合,后者远离活性位点的变构位点,稳定了激酶的非活性形式。 它以267 nM的IC50抑制Bcr-abl磷酸化,但不抑制包括天然c-Abl在内的63种其他激酶的组合,并且显示出对不表达Bcr-Abl的细胞完全缺乏毒性。 GNF-2对于新型抑制剂研究Bcr-abl活性并治疗由Bcr-Abl癌蛋白引起的耐药性慢性粒细胞白血病(CML)具有巨大潜力。

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Abl page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

性质

Quality Level  100
assay  ≥98% (HPLC)
form  solid
color  off-white
solubility  H2O: <2 mg/mL
 DMSO: ≥5 mg/mL
storage temp.  2-8°C
SMILES string  NC(=O)c1cccc(c1)-c2cc(Nc3ccc(OC(F)(F)F)cc3)ncn2
InChI  1S/C18H13F3N4O2/c19-18(20,21)27-14-6-4-13(5-7-14)25-16-9-15(23-10-24-16)11-2-1-3-12(8-11)17(22)26/h1-10H,(H2,22,26)(H,23,24,25)
InChI key  WEVYNIUIFUYDGI-UHFFFAOYSA-N


安全信息

个人防护装备 dust mask type N95 (US)EyeshieldsGloves
危害码 (欧洲) Xi
风险声明 (欧洲) 36/37/38
安全声明 (欧洲) 26
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16