General description
一种GJ072的活性模拟化合物。
GJ103 sodium salt is an active analog of the read-through compound GJ072. Some GJ072 analogs (e.g., GJ103, GJ106, GJ109, and GJ111) consistently demonstrates their activities in all three PTCs by both FCATMpSer1981 and IRIF assays. GJ103 have similar read-through activity as RTC13 or RTC14, but are more tolerable than RTC13 and RTC14 to A-T cells.
GJ103钠盐是通读化合物GJ072的活性类似物。 某些GJ072类似物(例如GJ103,GJ106,GJ109和GJ111)通过FCATMpSer1981和IRIF分析一致地证明了它们在所有三种PTC中的活性。 GJ103具有与RTC13或RTC14类似的通读活性,但对A-T细胞的耐受性比RTC13和RTC14高。
Properties
Iupac Name: | 2-((4-(3-methoxyphenyl)-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetic acid |
Inchi Code | 1S/C16H14N4O3S/c1-23-12-6-4-5-11(9-12)20-15(13-7-2-3-8-17-13)18-19-16(20)24-10-14(21)22/h2-9H,10H2,1H3,(H,21,22) |
Inchi Key | GBVQSAZHPCDBDY-UHFFFAOYSA-N |
安全信息