GGTI298三氟乙酸盐水合物，GGTI 298 trifluoroacetate salt hydrate；≥90% (HPLC), film

图片 GGTI298三氟乙酸盐水合物，GGTI 298 trifluoroacetate salt hydrate；≥90% (HPLC), film
别名：N-[[4-(2-(R)-Amino-3-mercaptopropyl)amino]-2-naphthylbenzoyl]leucine methyl ester trifluoroacetate salt hydrate；N-[[4-（2-（R）-氨基-3-巯基丙基）氨基] -2-萘基苯甲酰基]亮氨酸甲酯三氟乙酸盐水合物

Empirical Formula (Hill Notation): C27H33N3O3S · C2HF3O2 · xH2O CAS号: 1217457-86-7 分子量: 593.66 (anhydrous basis) MDL编号: MFCD06409252 PubChem化学物质编号: 24724490 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: G5169
CAS号: 1217457-86-7
MDL号: MFCD06409252
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说明

应用

GGTI 298 trifluoroacetate salt hydrate has been used as a geranylgeranyltransferase I (GGTase I) inhibitor:
  • to study the anticancer effects of statins along with GGTI 298[1]
  • to study its combinatorial effects with FTI-277 on statin-mediated activation of extracellular signal-regulated kinase 5 (ERK5) in the human endothelium[2]
  • to evaluate the effect of protein geranylgeranylation (GG) inhibition on the breast cancer stem cell (CSC) population[3]

生化/生理作用

GGTI 298 is a cell-permeable, prodrug form of the geranylgeranyltransferase I (GGTase I) inhibitor GGTI-297. It inhibits the processing of Rap 1A without effecting the processing of H-Ras.
 

特点和优势

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
 
 

属性

质量水平

100

测定

≥90% (HPLC)

形式

film
lyophilized

杂质

<10% dimer

颜色

colorless

mp

99.5-100 °C

溶解性

DMSO: >20 mg/mL

储存温度

−20°C

SMILES string

OC(=O)C(F)(F)F.COC(=O)[C@H](CC(C)C)NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c2cccc3ccccc23

InChI

1S/C27H33N3O3S.C2HF3O2/c1-17(2)13-25(27(32)33-3)30-26(31)23-12-11-20(29-15-19(28)16-34)14-24(23)22-10-6-8-18-7-4-5-9-21(18)22;3-2(4,5)1(6)7/h4-12,14,17,19,25,29,34H,13,15-16,28H2,1-3H3,(H,30,31);(H,6,7)/t19-,25+;/m1./s1

InChI key

WALKWJPZELDSKT-UFABNHQSSA-N

Gene Information

human ... PGGT1B(5229)

 

安全信息

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315 - H319 - H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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