Fmoc-S-乙酰氨甲基-L-半胱氨酸，Fmoc-Cys(Acm)-OH；Novabiochem®, ≥98%

图片 Fmoc-S-乙酰氨甲基-L-半胱氨酸，Fmoc-Cys(Acm)-OH；Novabiochem®, ≥98%
别名：Nα-芴甲氧羰酰基-S-乙酰氨甲基-L-半胱氨酸；N-α-Fmoc-S-acetamidomethyl-L-cysteine；8520060005

Empirical Formula (Hill Notation): C21H22N2O5S CAS号: 86060-81-3 分子量: 414.47 MDL编号: MFCD00038769
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: 8.52006
CAS号: 86060-81-3
MDL号: MFCD00038769
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说明

一般描述

The side-chain Acm group is stable to TFA but can be removed with Hg(II) [1] or Ag(I) [2] to give cysteinyl peptides, or oxidatively with Tl(III) [3] or I2 [4] to generate cystinyl peptides.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Fmoc SPPS of Cysteine-Containing Peptides

Literature references

[1] D. F. Veber, et al. (1972) J. Am. Chem. Soc., 94, 5456.
[2] M. Yoshida, et al. (1990) Chem. Pharm. Bull., 38, 273.
[3] N. Fujii, et al. (1987) Chem. Pharm. Bull., 36, 2339.
[4] B. Kamber, et al. (1980) Helv. Chim. Acta, 63, 899.
 

联系

Replaces: 04-12-1014
 

分析说明

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(011B)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (25 mmole in 50 ml DMF): clearly soluble
UV/VIS (E(450 bis 600 nm)): ≤ 50 mAU
Assay (acidimetric): ≥ 96.0 %
Water (K. F.): ≤ 5.00 %

To see the solvent systems used for TLC of Novabiochem® products please click here.
 

法律信息

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

 

属性

质量水平

200

产品线

Novabiochem®

检测方案

≥96.0% (acidimetric)
≥98% (TLC)
≥99.0% (HPLC)

形式

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

mp

147-150 °C

application(s)

peptide synthesis

官能团

thiol

储存温度

2-30°C

InChI

1S/C21H22N2O5S/c1-13(24)22-12-29-11-19(20(25)26)23-21(27)28-10-18-16-8-4-2-6-14(16)15-7-3-5-9-17(15)18/h2-9,18-19H,10-12H2,1H3,(H,22,24)(H,23,27)(H,25,26)/t19-/m0/s1

InChI key

CSMYOORPUGPKAP-IBGZPJMESA-N

 

安全信息

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315 - H319 - H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 30 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 30
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