Fmoc-S-三苯甲基-L-半胱氨酸，Fmoc-Cys(Trt)-OH；Novabiochem®, ≥99.0% (a/a)

别名：芴甲氧羰基-S-三苯甲基-L-半胱氨酸；N-(9-芴甲氧羰基)-S-三苯甲基-L-半胱氨酸；Nα-Fmoc-S-三苯甲基-L-半胱氨酸；Nα-Fmoc-S-trityl-L-cysteine, N-(9-Fluorenylmethoxycarbonyl)-S-trityl-L-cysteine；8520080025；8520080100；8520080250；8520080500；8520085000

Empirical Formula (Hill Notation): C37H31NO4S CAS号: 103213-32-7 分子量: 585.71 MDL编号: MFCD00038538

制造商品牌: 默克 Merck , 西格玛 Sigma-Aldrich

货号（SKU）: 8.52008

CAS号: 103213-32-7

MDL号: MFCD00038538

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说明

一般描述

High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities. The standard derivative for Fmoc SPPS of peptides containing Cys ^[1]. The Trt group is removed with 95% TFA containing 1-5% TIS. Ideally, this derivative should be introduced using the symmetrical anhydride or DIPCDI/HOBt activation ^[2,3] to minimize enantiomerization. If activation with uronium or phosphonium reagents, such as HBTU or PyBOP^®, is to be employed, it is strongly recommended that collidine is used as the base ^[4], as this has been shown to significantly reduce loss of optical integrity during coupling.

Associated Protocols and Technical Articles
Fmoc-amino acids for Peptide Production
Cleavage and Deprotection Protocols for Fmoc SPPS
Fmoc SPPS of Cysteine-Containing Peptides

Literature references

^[1] S. N. McCurdy (1989) Pept. Res., 2, 147.
^[2] T. Kaiser, et al. (1996) Tetrahedron Lett., 37, 1187.
^[3] Y. X. Han, et al. (1997) J. Org. Chem., 62, 4307.
^[4] Y. N. Angell (2002) J. Peptide Res., 5, 292.

联系

Replaces: 04-12-1018

分析说明

Colour (visual): white to off white
Appearance of substance (visual): powder
Colour index (0,5 M in DMF): ≤ 150 Hazen
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (HPLC): ≥ 99.0 % (a/a)
Fmoc-ß-Ala-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-ß-Ala-Cys (Trt) -OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-Cys(Trt)-Cys(Trt)-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-Cys-OH (HPLC): ≤ 0.1 % (a/a)
Assay free amino acid (HPLC): ≤ 0.2 %
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 98.0 %
Water (K. F.): ≤ 2.0 %
Ethyl acetate (HS-GC): ≤ 0.5 %
Acetate (IC): ≤ 0.02 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

法律信息

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

属性

质量水平

400

产品线

Novabiochem^®

检测方案

≥98% (TLC)
≥98.0% (acidimetric)
≥99.0% (HPLC)

形式

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem^®

mp

164-175 °C

application(s)

peptide synthesis

官能团

thiol

储存温度

−20°C (−15°C to −25°C)

InChI

1S/C37H31NO4S/c39-35(40)34(38-36(41)42-24-33-31-22-12-10-20-29(31)30-21-11-13-23-32(30)33)25-43-37(26-14-4-1-5-15-26,27-16-6-2-7-17-27)28-18-8-3-9-19-28/h1-23,33-34H,24-25H2,(H,38,41)(H,39,40)/p-1/t34-/m0/s1

InChI key

KLBPUVPNPAJWHZ-UMSFTDKQSA-M

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格

属性名称	属性值
储存温度 Storage temp.	2-8°C冷藏
全球实时库存 Availability √	美国St. Louis ≥ 30 \| 欧洲Eur. ≥ 10 \| 東京Tokyo ≥ 9 \| 香港与北京 ≥ 30

商品标签 [tags]

fmoc-cys(trt)-oh (2)

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