DREADD激动剂21二盐酸盐，DREADD Agonist 21 dihydrochloride；≥98% (HPLC)

图片 DREADD激动剂21二盐酸盐，DREADD Agonist 21 dihydrochloride；≥98% (HPLC)
别名：11-(1-哌嗪基)-5H-二苯并[b,e][1，4]二氮卓类二盐酸盐；11-(1-哌嗪基)-5H-二苯并[b,e][1,4]二氮卓类；11-哌嗪基二苯并[b,e][1,4]二氮卓类二盐酸盐；11-(1-piperazinyl)-5H-Dibenzo[b,e][1,4]diazepine dihydrochloride, 11-(Piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine; 11-Piperazinyldibenzo[b,e][1,4]diazepine dihydrochloride, Compound 21 dihydrochloride

Empirical Formula (Hill Notation): C17H18N4 · 2HCl CAS号: 56296-18-5 分子量: 351.27 MDL编号: MFCD25121806
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: SML2392
CAS号: 56296-18-5
MDL号: MFCD25121806
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

说明

生化/生理作用

Compound 21 is a potent designer drug with full agonist activity toward human hM3Dq (EC50 = 1.7 nM by cell-based Ca2+ mobilization assay), a human M3 muscarinic receptor (M3R)-based Gq (M3Dq) DREADD (Designer Receptors Exclusively Activated by Designer Drugs), displaying little activity toward muscarinic acetylcholine receptor M3 (30% M3 activation at 10 μM) and reduced affinity toward H1, 5HT2A, 5HT2C, α1A receptor (fold selectivity = 3.5, 40, 100, 165, respectively). Note: the DREADD hM3Dq exhibits M3 biological activity, but is insensitive to the endogenous ligand acetylcholine (ACh).
 
 

属性

检测方案

≥98% (HPLC)

形式

powder

储存条件

desiccated

颜色

yellow to brown

溶解性

H2O: 2 mg/mL, clear

储存温度

−20°C

SMILES string

C1(C=CC=C2)=C2C(N3CCNCC3)=NC(C=CC=C4)=C4N1

 

安全信息

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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