dPPA [DOPPA]，≥98%, HPLC

图片 dPPA [DOPPA]，≥98%, HPLC
别名：12-脱氧佛波醇13-苯乙酸酯20-乙酸酯；12-Deoxyphorbol 13-phenylacetate 20-acetate

Empirical Formula (Hill Notation): C30H36O7 CAS号: 54662-30-5 分子量: 508.60 MDL编号: MFCD01741294 PubChem化学物质编号: 329798788 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: D7821
CAS号: 54662-30-5
MDL号: MFCD01741294
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说明

dPPA是一种佛波醇酯，可选择性激活PKC的β同种型。它对PKC-β的效力大约是α、γ或δ同种型的100倍。PKC家族成员各有特定的功能，但PKC-β和δ似乎具有相似的表达谱，并且都参与调节细胞凋亡和B细胞活化，因此dPPA是确定PKCβ特异性信号事件的有用工具。

应用

dPPA/phorbol ester 12-deoxyphorbol 13-phenylacetate 20-acetate (DOPPA) may be used as a potent activator of PKC-β:
  • to treat transfected HT-22 cells to promote phosphorylation of p66Shc[1]
  • to treat HT-22 and B12 cells to study its effects on cell viability[1]
  • to treat neurons and measure primary cortical neurons using the 2,5-diphenyl-2H-tetrazolium bromide (MTT) assay[1]

生化/生理作用

dPPA is a phorbol ester that selectively activates the β isotype of PKC. It is approximately 100-fold more potent for PKC-β than the α, γ or δ isotypes. PKC family members each have specific functions, but PKC-β and δ appear to share similar expression profiles, and both are involved in regulating apoptosis and B cell activation, thus dPPA is a useful tool in determining PKCβ specific signaling events.
 

特点和优势

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
 
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

oil

颜色

colorless to light yellow

储存温度

−20°C

SMILES string

CC(C1=O)=C[C@]2([H])[C@]1(O)CC(COC(C)=O)=C[C@]3([H])[C@]2(O)[C@H](C)C[C@]4(OC(CC5=CC=CC=C5)=O)[C@H]3C4(C)C

InChI

1S/C30H36O7/c1-17-11-23-28(34,26(17)33)15-21(16-36-19(3)31)12-22-25-27(4,5)29(25,14-18(2)30(22,23)35)37-24(32)13-20-9-7-6-8-10-20/h6-12,18,22-23,25,34-35H,13-16H2,1-5H3/t18-,22+,23-,25-,28-,29+,30-/m1/s1

InChI key

MEDVHSNRBPAIPU-XMOZQXTISA-N

 

安全信息

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险分类

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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