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D-2-脱氧葡萄糖 [2-脱氧-D-葡萄糖, 2-DG],2-Deoxy-D-glucose;BioXtra, ≥98%

别名:2-脱氧-D-葡糖,2-脱氧葡萄糖,2-去氧-D-葡萄糖, 2-Deoxy-D-arabinohexose, 2-Deoxyglucose

CAS号 154-17-6 经验分子式(希尔表示法) C6H12O5 分子量 164.16 Beilstein/REAXYS Number 1723331 EINECS 编号 205-823-0 MDL number MFCD00151328 PubChem Substance ID 24893732 NACRES NA.25
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): D3179
CAS号: 154-17-6
MDL号: MFCD00151328
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$448.77

产品描述

Application

2-Deoxy-D-glucose was used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.[1][2] It was used in glucoprivic feeding research to invoke and study the processes of counter-regulatory response (CRR).[3]

包装

1, 5 g in poly bottle

250 mg in poly bottle

Biochem/physiol Actions

2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its action on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increases ROS production, and activate AMPK.[2]

2-脱氧-D-葡萄糖(2-脱氧葡萄糖)是一种葡萄糖类似物,可通过作用于己糖激酶这一糖酵解限速步骤来抑制糖酵解。 它会被己糖激酶磷酸化为不能被磷酸葡萄糖异构酶进一步代谢的2-DG-P。 这将导致2-DG-P在细胞中的集聚以及细胞ATP的缺失。在体外,2-脱氧葡萄糖已显示出可诱导自噬、提高ROS的产生并激活AMPK。

性质

Quality Level200
biological sourcesynthetic (organic)
product lineBioXtra
assay≥98%
formpowder
application(s)gas chromatography (GC): suitable
impurities≤0.001% Phosphorus (P)
<0.1% Insoluble matter
ign. residue<0.1%
mp146-147 °C (lit.)
solubilityH2O: 1 M at 20 °C, clear, colorless
anion traceschloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%
cation tracesAl: ≤0.0005%
Ca: ≤0.003%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.005%
Pb: ≤0.001%
Zn: ≤0.0005%
storage temp.2-8°C
SMILES stringOC[C@@H](O)[C@@H](O)[C@H](O)CC=O
InChI1S/C6H12O5/c7-2-1-4(9)6(11)5(10)3-8/h2,4-6,8-11H,1,3H2/t4-,5-,6+/m1/s1
InChI keyVRYALKFFQXWPIH-PBXRRBTRSA-N


安全信息

个人防护装备 EyeshieldsGlovestype N95 (US)
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16