D-2-脱氧葡萄糖 [2-脱氧-D-葡萄糖]，2-Deoxy-D-glucose [2-DG]；BioXtra, ≥98%

别名：2-脱氧-D-葡糖，2-脱氧葡萄糖，2-去氧-D-葡萄糖， 2-Deoxy-D-arabinohexose, 2-Deoxyglucose

Empirical Formula (Hill Notation): C6H12O5 CAS号: 154-17-6 分子量: 164.16 Beilstein: 1723331 EC 号: 205-823-0 MDL编号: MFCD00151328 PubChem化学物质编号: 24893732 NACRES: NA.25

制造商品牌: 西格玛 Sigma-Aldrich

货号（SKU）: D3179

CAS号: 154-17-6

MDL号: MFCD00151328

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目录规格.SKU-Variant

说明

2-脱氧-D-葡萄糖用于开发涉及放射和化学增敏以及氧化应激的抗癌策略。[1] [2]它被用于葡萄糖喂养研究，以调用和研究反调节反应（CRR）的过程。

应用

2-Deoxy-D-glucose was used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.[1][2] It was used in glucoprivic feeding research to invoke and study the processes of counter-regulatory response (CRR).[3]

生化/生理作用

2-脱氧-D-葡萄糖（2-脱氧葡萄糖）是一种葡萄糖类似物，可通过作用于己糖激酶这一糖酵解限速步骤来抑制糖酵解。它会被己糖激酶磷酸化为不能被磷酸葡萄糖异构酶进一步代谢的2-DG-P。这将导致2-DG-P在细胞中的集聚以及细胞ATP的缺失。在体外，2-脱氧葡萄糖已显示出可诱导自噬、提高ROS的产生并激活AMPK。

2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its action on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increases ROS production, and activate AMPK.[2]

属性

生物来源

synthetic (organic)

质量水平

200

产品线

BioXtra

测定

≥98%

形式

powder

technique(s)

gas chromatography (GC): suitable

杂质

≤0.001% Phosphorus (P)
<0.1% Insoluble matter

灼烧残渣

<0.1%

mp

146-147 °C (lit.)

溶解性

H₂O: 1 M at 20 °C, clear, colorless

痕量阴离子

chloride (Cl^-): ≤0.05%
sulfate (SO₄^2-): ≤0.05%

痕量阳离子

Al: ≤0.0005%
Ca: ≤0.003%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.001%
NH₄⁺: ≤0.05%
Na: ≤0.005%
Pb: ≤0.001%
Zn: ≤0.0005%

储存温度

2-8°C

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)CC=O

InChI

1S/C6H12O5/c7-2-1-4(9)6(11)5(10)3-8/h2,4-6,8-11H,1,3H2/t4-,5-,6+/m1/s1

InChI key

VRYALKFFQXWPIH-PBXRRBTRSA-N

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格

属性名称	属性值
储存温度 Storage temp.	2-8°C冷藏
全球实时库存 Availability √	美国St. Louis ≥ 20 \| 欧洲Eur. ≥ 16 \| 東京Tokyo ≥ 5 \| 香港与北京 ≥ 20

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