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CYC116,≥99%(HPLC)

别名:4-methyl-5-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)thiazol-2-amine;4-甲基-5-(2-((4-吗啉苯基)氨基)嘧啶-4-基)噻唑-2-胺

CAS:693228-63-6;分子式:C18H20N6Os;分子量:368.46;MDL:MFCD14155805
制造商品牌: BSZH 科学公司
货号(SKU): C06068
CAS号: 693228-63-6
MDL号: MFCD14155805
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¥973.00

Properties

一种具有生物活性的小分子多激酶抑制剂,具有抗肿瘤活性,抑制Aurora A/B,Ki分别为8.0 nM和9.2 nM。

CYC116 is an orally bioavailable small molecule multi-kinase inhibitor with antineoplastic activity. Aurora kinase/VEGFR 2 inhibitor CYC116 inhibits Aurora kinases A and B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis. Aurora kinases are serine/threonine protein kinases that are only expressed in actively dividing cells and are critical in division or mitosis. VEGFR2 is a receptor tyrosine kinase that appears to account for most of the mitogenic and chemotactic effects of vascular endothelial growth factor (VEGF) on adult endothelial cells.

CYC116是一种具有抗肿瘤活性的口服生物利用型小分子多激酶抑制剂。 Aurora激酶/ VEGFR 2抑制剂CYC116抑制Aurora激酶A和B和血管内皮生长因子受体2(VEGFR2),导致细胞周期中断,细胞快速死亡和血管生成抑制。 极光激酶是丝氨酸/苏氨酸蛋白激酶,仅在活跃分裂的细胞中表达,对分裂或有丝分裂至关重要。 VEGFR2是一种酪氨酸激酶,似乎可以解释血管内皮生长因子(VEGF)对成年内皮细胞的大部分促有丝分裂和趋化作用。

Iupac Name4-methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine
Inchi Code1S/C18H20N6OS/c1-12-16(26-17(19)21-12)15-6-7-20-18(23-15)22-13-2-4-14(5-3-13)24-8-10-25-11-9-24/h2-7H,8-11H2,1H3,(H2,19,21)(H,20,22,23)
Inchi KeyGPSZYOIFQZPWEJ-UHFFFAOYSA-N


Description

Synonym4-methyl-5-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)thiazol-2-amine
Purity99%


安全信息

RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16
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